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A Cytomeglaoviral Protein Reveales a Dual Role for STAT2 in IFN-g Signaling and Antiviral Responses
The Journal of experimental medicine, 201 (2005), 10; 1543-1553. urn:nbn:hr:184:307988
Zimmermann, Albert; Trilling, Mirko; Wagner, Markus; Wilborn, Manuel; Bubić, Ivan; Jonjić, Stipan; Koszinowski, Ulrich; Hengel, Hartmut

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Zimmermann, A., Trilling, M., Wagner, M., Wilborn, M., Bubić, I., Jonjić, S. ... Hengel, H. (2005). A Cytomeglaoviral Protein Reveales a Dual Role for STAT2 in IFN-g Signaling and Antiviral Responses. The Journal of experimental medicine, 201. (10), 1543-1553. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:307988

Zimmermann, Albert, et al. "A Cytomeglaoviral Protein Reveales a Dual Role for STAT2 in IFN-g Signaling and Antiviral Responses." The Journal of experimental medicine, vol. 201, br. 10, 2005, str. 1543-1553. https://urn.nsk.hr/urn:nbn:hr:184:307988

Zimmermann, Albert, Mirko Trilling, Markus Wagner, Manuel Wilborn, Ivan Bubić, Stipan Jonjić, Ulrich Koszinowski i Hartmut Hengel. "A Cytomeglaoviral Protein Reveales a Dual Role for STAT2 in IFN-g Signaling and Antiviral Responses." The Journal of experimental medicine 201, br. 10 (2005): 1543-1553. https://urn.nsk.hr/urn:nbn:hr:184:307988

Zimmermann, A., et al. (2005) 'A Cytomeglaoviral Protein Reveales a Dual Role for STAT2 in IFN-g Signaling and Antiviral Responses', The Journal of experimental medicine, 201(10), str. 1543-1553. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:307988 (Datum pristupa: 25.12.2024.)

Zimmermann A, Trilling M, Wagner M, Wilborn M, Bubić I, Jonjić S, i sur.. A Cytomeglaoviral Protein Reveales a Dual Role for STAT2 in IFN-g Signaling and Antiviral Responses. The Journal of experimental medicine [Internet]. 2005. [pristupljeno 25.12.2024.];201(10):1543-1553. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:307988

A. Zimmermann, et al., "A Cytomeglaoviral Protein Reveales a Dual Role for STAT2 in IFN-g Signaling and Antiviral Responses", The Journal of experimental medicine, vol. 201, br. 10, str. 1543-1553, 2005. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:307988. [Citirano: 25.12.2024.]

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Naslov (engleski)A Cytomeglaoviral Protein Reveales a Dual Role for STAT2 in IFN-g Signaling and Antiviral Responses
AutorAlbert Zimmermann
AutorMirko Trilling
AutorMarkus Wagner
AutorManuel Wilborn
AutorIvan Bubić
AutorStipan Jonjić
AutorUlrich Koszinowski
AutorHartmut Hengel
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
A mouse cytomegalovirus (MCMV) gene conferring interferon (IFN) resistance was identified. This gene, M27, encodes a 79 kDa protein which is selcetively binding and down-regulating STAT2 but has no effect on STAT1 activation and signaling. The absence of pM27 conferred MCMV susceptibility to type I IFNs (a/b) but had a much more dramatic effect to type II IFN (g) in vitro and in vivo. Comparative analysis of M27+ and M27- MCMV revealed that the antiviral efficiency of IFN-g was partially dependent on the synergistic action of type I IFNs which required STAT2. Moreover, STAT2 was directly activated by IFN-g. This effect required IFNGR expression and was independent of type I IFNs. IFN-g induced incerasing levels of tyrosine-phosphorylated STAT2 in M27- MCMV infected cells which were esential for the antiviral potency of IFN-g. pM27 represents a new strategy for simultaneous evasion from type I and type II IFN and documents a hitherto unknown biological significance of STAT2 in antiviral IFN-g responses.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaThe Journal of experimental medicine
Brojčani podacivol. 201, br. 10, str. 1543-1553
p-ISSN0022-1007
URN:NBNurn:nbn:hr:184:307988
Datum objave publikacije2005
URL dokumentahttp://bib.irb.hr/190510
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2018-12-03 17:31:45