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Scientific paper - Original scientific paper
A Cytomeglaoviral Protein Reveales a Dual Role for STAT2 in IFN-g Signaling and Antiviral Responses
The Journal of experimental medicine, 201 (2005), 10; 1543-1553. urn:nbn:hr:184:307988
Zimmermann, Albert; Trilling, Mirko; Wagner, Markus; Wilborn, Manuel; Bubić, Ivan; Jonjić, Stipan; Koszinowski, Ulrich; Hengel, Hartmut

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Zimmermann, A., Trilling, M., Wagner, M., Wilborn, M., Bubić, I., Jonjić, S. ... Hengel, H. (2005). A Cytomeglaoviral Protein Reveales a Dual Role for STAT2 in IFN-g Signaling and Antiviral Responses. The Journal of experimental medicine, 201. (10), 1543-1553. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:307988

Zimmermann, Albert, et al. "A Cytomeglaoviral Protein Reveales a Dual Role for STAT2 in IFN-g Signaling and Antiviral Responses." The Journal of experimental medicine, vol. 201, no. 10, 2005, pp. 1543-1553. https://urn.nsk.hr/urn:nbn:hr:184:307988

Zimmermann, Albert, Mirko Trilling, Markus Wagner, Manuel Wilborn, Ivan Bubić, Stipan Jonjić, Ulrich Koszinowski and Hartmut Hengel. "A Cytomeglaoviral Protein Reveales a Dual Role for STAT2 in IFN-g Signaling and Antiviral Responses." The Journal of experimental medicine 201, no. 10 (2005): 1543-1553. https://urn.nsk.hr/urn:nbn:hr:184:307988

Zimmermann, A., et al. (2005) 'A Cytomeglaoviral Protein Reveales a Dual Role for STAT2 in IFN-g Signaling and Antiviral Responses', The Journal of experimental medicine, 201(10), pp. 1543-1553. Available at: https://urn.nsk.hr/urn:nbn:hr:184:307988 (Accessed 25 December 2024)

Zimmermann A, Trilling M, Wagner M, Wilborn M, Bubić I, Jonjić S, and sur.. A Cytomeglaoviral Protein Reveales a Dual Role for STAT2 in IFN-g Signaling and Antiviral Responses. The Journal of experimental medicine [Internet]. 2005 [cited 2024 December 25];201(10):1543-1553. Available at: https://urn.nsk.hr/urn:nbn:hr:184:307988

A. Zimmermann, et al., "A Cytomeglaoviral Protein Reveales a Dual Role for STAT2 in IFN-g Signaling and Antiviral Responses", The Journal of experimental medicine, vol. 201, no. 10, pp. 1543-1553, 2005. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:307988. [Accessed: 25 December 2024]

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Metadata
Title (english)A Cytomeglaoviral Protein Reveales a Dual Role for STAT2 in IFN-g Signaling and Antiviral Responses
AuthorAlbert Zimmermann
AuthorMirko Trilling
AuthorMarkus Wagner
AuthorManuel Wilborn
AuthorIvan Bubić
AuthorStipan Jonjić
AuthorUlrich Koszinowski
AuthorHartmut Hengel
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
A mouse cytomegalovirus (MCMV) gene conferring interferon (IFN) resistance was identified. This gene, M27, encodes a 79 kDa protein which is selcetively binding and down-regulating STAT2 but has no effect on STAT1 activation and signaling. The absence of pM27 conferred MCMV susceptibility to type I IFNs (a/b) but had a much more dramatic effect to type II IFN (g) in vitro and in vivo. Comparative analysis of M27+ and M27- MCMV revealed that the antiviral efficiency of IFN-g was partially dependent on the synergistic action of type I IFNs which required STAT2. Moreover, STAT2 was directly activated by IFN-g. This effect required IFNGR expression and was independent of type I IFNs. IFN-g induced incerasing levels of tyrosine-phosphorylated STAT2 in M27- MCMV infected cells which were esential for the antiviral potency of IFN-g. pM27 represents a new strategy for simultaneous evasion from type I and type II IFN and documents a hitherto unknown biological significance of STAT2 in antiviral IFN-g responses.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleThe Journal of experimental medicine
Numberingvol. 201, no. 10, pp. 1543-1553
p-ISSN0022-1007
URN:NBNurn:nbn:hr:184:307988
Publication2005
Document URLhttp://bib.irb.hr/190510
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-12-03 17:31:45