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PATOGENETSKI MEHANIZAM SINDROMA ZAKAŠNJELE MIŠIĆNE BOLI
Medicina Fluminensis : Medicina Fluminensis, 43. (2007), 3; 179-187. urn:nbn:hr:184:232500
Ravlić-Gulan, Jagoda; Schnurrer-Luke-Vrbanić, Tea; Boschi, Vladimir; Vogrin, Matjaž

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Ravlić Gulan, J., Schnurrer Luke Vrbanić, T., Boschi, V. & Vogrin, M. (2007). PATOGENETSKI MEHANIZAM SINDROMA ZAKAŠNJELE MIŠIĆNE BOLI. Medicina Fluminensis : Medicina Fluminensis, 43.. (3), 179-187. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:232500

Ravlić Gulan, Jagoda, et al. "PATOGENETSKI MEHANIZAM SINDROMA ZAKAŠNJELE MIŠIĆNE BOLI." Medicina Fluminensis : Medicina Fluminensis, vol. 43., no. 3, 2007, pp. 179-187. https://urn.nsk.hr/urn:nbn:hr:184:232500

Ravlić Gulan, Jagoda, Tea Schnurrer Luke Vrbanić, Vladimir Boschi and Matjaž Vogrin. "PATOGENETSKI MEHANIZAM SINDROMA ZAKAŠNJELE MIŠIĆNE BOLI." Medicina Fluminensis : Medicina Fluminensis 43., no. 3 (2007): 179-187. https://urn.nsk.hr/urn:nbn:hr:184:232500

Ravlić Gulan, J., et al. (2007) 'PATOGENETSKI MEHANIZAM SINDROMA ZAKAŠNJELE MIŠIĆNE BOLI', Medicina Fluminensis : Medicina Fluminensis, 43.(3), pp. 179-187. Available at: https://urn.nsk.hr/urn:nbn:hr:184:232500 (Accessed 01 October 2024)

Ravlić Gulan J, Schnurrer Luke Vrbanić T, Boschi V, Vogrin M. PATOGENETSKI MEHANIZAM SINDROMA ZAKAŠNJELE MIŠIĆNE BOLI. Medicina Fluminensis : Medicina Fluminensis [Internet]. 2007 September 20 [cited 2024 October 01];43.(3):179-187. Available at: https://urn.nsk.hr/urn:nbn:hr:184:232500

J. Ravlić Gulan, T. Schnurrer Luke Vrbanić, V. Boschi and M. Vogrin, "PATOGENETSKI MEHANIZAM SINDROMA ZAKAŠNJELE MIŠIĆNE BOLI", Medicina Fluminensis : Medicina Fluminensis, vol. 43., no. 3, pp. 179-187, September 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:232500. [Accessed: 01 October 2024]

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Metadata
Title (croatian)PATOGENETSKI MEHANIZAM SINDROMA ZAKAŠNJELE MIŠIĆNE BOLI
Title (english)THE PATHOGENETIC MECHANISM IN DELAYED ONSET MUSCLE SORENES
AuthorJagoda Ravlić-Gulan
AuthorTea Schnurrer-Luke-Vrbanić
AuthorVladimir Boschi
AuthorMatjaž Vogrin
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (croatian)
SAŽETAK Zakašnjela (odgođena) mišićna bol (DOMS, od. engl. delayed onset muscle soreness) sindrom je koji obuhvaća slabost mišića, bol, duboku osjetljivost u mišićima koja se javlja obično 24–48 sati nakon neuobičajene ili jako intenzivne tjelesne aktivnosti, a prolazi za 5–7 dana. Usprkos brojnim studijama koje se bave ovom problematikom, još nisu usuglašeni stavovi ni o mogućem patogenetskom mehanizmu DOMS-a niti o terapijskim ili preventivnim mogućnostima. Kao glavni uzročni čimbenik pojave DOMS-a navodi se ekscentrična kontrakcija u kojoj se mišić tijekom održavanja napetosti produžuje, ali mehanizam koji to objašnjava nije poznat. Ekscentrična aktivnost mišića može inducirati ozljedu mišićne stanice, koja se manifestira kao oštećenje miofibrilarnih i citoskeletnih struktura, gubitak mišićne snage i poremećaj slijeda aktiviranja motoričkih jedinica, promjena metaboličkih zbivanja u stanici i izlazak enzima u cirkulaciju. Novija istraživanja govore o mogućnosti da bol nije uzrokovana isključivo mehaničkim oštećenjima mišićne stanice i sekundarnim upalnim odgovorima koji podražuje nociceptore, već adaptacijskim procesima remodeliranja mišićne stanice, kojima se povećava snaga mišića dodavanjem novih sarkomera (sarkomerogeneza) i time štiti mišić od novih ozljeda. U ovom radu donosimo pregled dosadašnjih spoznaja o promjenama u mišićnoj stanici, za koje se misli da su uključene u patofiziološki mehanizam nastanka odgođene boli u DOMS sindromu, a čije bi razjašnjavanje moglo imati široku kliničku primjenu u sportskoj medicini.
Abstract (english)
SUMMARY Delayed onset muscle soreness (DOMS) is the feeling of pain, tenderness, deep ache and stiffness that usually develops 24-48 hours after an unaccustomed or a high intensity exercise and subsides generally within 5 to 7 days. Despite numerous studies there is no general consensus on the underlying mechanisms of DOMS, treatment or prevention strategies. A major causative factor is eccentric muscle actions, i.e. active resistance to muscle lengthening. However, the cellular basis for this response remains unclear. Eccentric activities induce micro-injury of muscle cells resulting in myofibrillar disruption, prolonged loss of muscle strength, decrements in motor control, changes in energy substrate levels and presence of muscle proteins in the blood. Some recent research claims that DOMS is not caused by the pain from damaged muscle cells and secondary induced inflammatory processes, but from the reinforcement process. The biological response of muscle to eccentric contractions results in strengthening and protection from further injury. The muscle responds to training by reinforcing itself up to and above its previous strength by adding new sarcomeres, the segments in the muscle fibrils (sarcomerogenesis). In this review, we summarize the muscle cell disturbances and adaptation processes known to be involved in pathogenetic mechanisms of DOMS which could be of clinical importance in sports medicine.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis : Medicina Fluminensis
Numberingvol. 43., no. 3, pp. 179-187
p-ISSN0025-7729
URN:NBNurn:nbn:hr:184:232500
Publication2007-09-20
Document URLhttp://hrcak.srce.hr/23419
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-04-27 16:52:27