prikaz prve stranice dokumenta Cell Death and Cell Proliferation in Mouse Submandibular Gland during Early Post-irradiation Phase
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Scientific paper - Original scientific paper
Cell Death and Cell Proliferation in Mouse Submandibular Gland during Early Post-irradiation Phase
Acta medica Okayama, 59 (2005), 4; 153-159. urn:nbn:hr:184:671192
Bralić, Marina; Muhvić Urek, Miranda; Stemberga, Valter; Golemac, Mijo; Jurković, Slaven; Borčić, Josipa; Braut, Alen; Tomac, Jelena

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Bralić, M., Muhvić Urek, M., Stemberga, V., Golemac, M., Jurković, S., Borčić, J. ... Tomac, J. (2005). Cell Death and Cell Proliferation in Mouse Submandibular Gland during Early Post-irradiation Phase. Acta medica Okayama, 59. (4), 153-159. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:671192

Bralić, Marina, et al. "Cell Death and Cell Proliferation in Mouse Submandibular Gland during Early Post-irradiation Phase." Acta medica Okayama, vol. 59, no. 4, 2005, pp. 153-159. https://urn.nsk.hr/urn:nbn:hr:184:671192

Bralić, Marina, Miranda Muhvić Urek, Valter Stemberga, Mijo Golemac, Slaven Jurković, Josipa Borčić, Alen Braut and Jelena Tomac. "Cell Death and Cell Proliferation in Mouse Submandibular Gland during Early Post-irradiation Phase." Acta medica Okayama 59, no. 4 (2005): 153-159. https://urn.nsk.hr/urn:nbn:hr:184:671192

Bralić, M., et al. (2005) 'Cell Death and Cell Proliferation in Mouse Submandibular Gland during Early Post-irradiation Phase', Acta medica Okayama, 59(4), pp. 153-159. Available at: https://urn.nsk.hr/urn:nbn:hr:184:671192 (Accessed 12 November 2024)

Bralić M, Muhvić Urek M, Stemberga V, Golemac M, Jurković S, Borčić J, and sur.. Cell Death and Cell Proliferation in Mouse Submandibular Gland during Early Post-irradiation Phase. Acta medica Okayama [Internet]. 2005 [cited 2024 November 12];59(4):153-159. Available at: https://urn.nsk.hr/urn:nbn:hr:184:671192

M. Bralić, et al., "Cell Death and Cell Proliferation in Mouse Submandibular Gland during Early Post-irradiation Phase", Acta medica Okayama, vol. 59, no. 4, pp. 153-159, 2005. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:671192. [Accessed: 12 November 2024]

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Metadata
Title (english)Cell Death and Cell Proliferation in Mouse Submandibular Gland during Early Post-irradiation Phase
AuthorMarina Bralić
AuthorMiranda Muhvić Urek
AuthorValter Stemberga
AuthorMijo Golemac
MBZ: 247605
AuthorSlaven Jurković
AuthorJosipa Borčić
AuthorAlen Braut
AuthorJelena Tomac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Oncology and Radiotherapy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Prosthodontics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Forensic Medicine and Criminalistics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The effects of irradiation on different cell compartments in submandibular gland were analyzed in adult C57BL/6 mice exposed to X-ray irradiation and followed up for 10 days. Apoptosis was quantified using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-digoxigenin nick end labeling method (TUNEL). Cell proliferation was detected using immunohistochemistry for proliferating cell nuclear antigen (PCNA). Radiation induced apoptosis occurred rapidly, with maximum observed 3 days post-irradiation. The percentage of apoptotic cells increased with the irradiation dose. One-day post-irradiation cell proliferation was significantly reduced in comparison to sham-irradiated controls. After post-irradiation arrest of the cell cycle, proliferation increased in all gland compartments reaching the maximum at day 6 post-irradiation. Proliferation response was equivalent with dose of irradiation. We suggest that reason for gland dysfunction could be co existing of high apoptotic and proliferative activity that is going on in irradiated gland.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa medica Okayama
Numberingvol. 59, no. 4, pp. 153-159
p-ISSN0386-300X
URN:NBNurn:nbn:hr:184:671192
Publication2005
Document URLhttp://bib.irb.hr/210523
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2020-04-19 19:17:37