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The diagnostic yield of non-invasive testing features in cardiac amyloidosis
Nuclear Medicine Review, 28 (2025); 1-8. https://doi.org/10.5603/nmr.103627
Kustić, Domagoj; Vukšić, Josipa; Huić, Dražen

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Kustić, D., Vukšić, J. i Huić, D. (2025). The diagnostic yield of non-invasive testing features in cardiac amyloidosis. Nuclear Medicine Review, 28., 1-8. doi: 10.5603/nmr.103627

Kustić, Domagoj, et al. "The diagnostic yield of non-invasive testing features in cardiac amyloidosis." Nuclear Medicine Review, vol. 28, 2025, str. 1-8. https://doi.org/10.5603/nmr.103627

Kustić, Domagoj, Josipa Vukšić i Dražen Huić. "The diagnostic yield of non-invasive testing features in cardiac amyloidosis." Nuclear Medicine Review 28 (2025): 1-8. https://doi.org/10.5603/nmr.103627

Kustić, D., Vukšić, J. i Huić, D. (2025) 'The diagnostic yield of non-invasive testing features in cardiac amyloidosis', Nuclear Medicine Review, 28, str. 1-8. doi: 10.5603/nmr.103627

Kustić D, Vukšić J, Huić D. The diagnostic yield of non-invasive testing features in cardiac amyloidosis. Nuclear Medicine Review [Internet]. 10.03.2025. [pristupljeno 02.04.2025.];28:1-8. doi: 10.5603/nmr.103627

D. Kustić, J. Vukšić i D. Huić, "The diagnostic yield of non-invasive testing features in cardiac amyloidosis", Nuclear Medicine Review, vol. 28, str. 1-8, Ožujak 2025. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:252353. [Citirano: 02.04.2025.]

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Podaci o radu
Naslov (engleski)The diagnostic yield of non-invasive testing features in cardiac amyloidosis
AutorDomagoj Kustić
AutorJosipa Vukšić
AutorDražen Huić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za nuklearnu medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Nuklearna medicina
Sažetak (engleski)
Background: Cardiac amyloidosis (CA) is a progressive disease in which amyloid fibrils infiltrate the heart muscle. This study aimed to identify features from cardiac biomarkers, electrocardiography (ECG), and echocardiography that may distinguish between transthyretin amyloidosis (ATTR) scintigraphy-positive and negative patients. Material and methods: Seventy-eight consecutive patients, median age 69 years (range 34–81), with suspected CA, negative serum free light chains, and negative serum... Više and urine protein electrophoresis with immunofixation, referred to cardiac scintigraphy between 2021 and 2024, were retrospectively enrolled. Cardiac uptake was assessed by Perugini grades. Troponin T, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and various ECG and echocardiographic features were compared between ATTR scintigraphy-positive and negative participants using the t-test, Mann–Whitney U-test, and χ2-test as appropriate. Multivariable stepwise logistic regression created the prediction model for ATTR-positive scintigraphy. The significance level was 0.05. Results: Scintigraphy was ATTR-positive in 24 participants (30.77%). The variables significantly connected with ATTR-positive testing were atrial fibrillation (p = 0.010), first- or second-degree atrioventricular block (p = 0.041), left ventricle (LV) end-diastolic dimension (p = 0.018), LV global longitudinal strain (GLS) (p = 0.040), a restrictive transmitral inflow pattern (p = 0.025), LV posterior wall thickness (p < 0.001), interventricular septum (IVS) thickness (p < 0.001), QRS voltages (p < 0.001), the pseudo-infarct pattern (p < 0.001), and relative apical sparing of the GLS ratio (p < 0.001). The latter four were incorporated into the prediction model for ATTR-positive scintigraphy. Conclusions: ECG and echocardiography remain the essential diagnostic procedures that raise the suspicion of CA and trigger further diagnostics. Low QRS voltages, the pseudo-infarct pattern, IVS thickness, and relative apical sparing of the GLS ratio are sensitive predictors of ATTR-positive scintigraphy findings. Sakrij dio sažetka
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNuclear Medicine Review
Brojčani podacivol. 28, br. 0, str. 1-8
p-ISSN1506-9680
e-ISSN1644-4345
DOIhttps://doi.org/10.5603/nmr.103627
URN:NBNurn:nbn:hr:184:252353
Datum objave publikacije2025-03-10
URL dokumentahttps://journals.viamedica.pl/nuclear_medicine_review/article/view/103627
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2025-03-28 08:15:14
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