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Scientific paper - Original scientific paper
The diagnostic yield of non-invasive testing features in cardiac amyloidosis
Nuclear Medicine Review, 28 (2025); 1-8. https://doi.org/10.5603/nmr.103627
Kustić, Domagoj; Vukšić, Josipa; Huić, Dražen

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Kustić, D., Vukšić, J. & Huić, D. (2025). The diagnostic yield of non-invasive testing features in cardiac amyloidosis. Nuclear Medicine Review, 28., 1-8. doi: 10.5603/nmr.103627

Kustić, Domagoj, et al. "The diagnostic yield of non-invasive testing features in cardiac amyloidosis." Nuclear Medicine Review, vol. 28, 2025, pp. 1-8. https://doi.org/10.5603/nmr.103627

Kustić, Domagoj, Josipa Vukšić and Dražen Huić. "The diagnostic yield of non-invasive testing features in cardiac amyloidosis." Nuclear Medicine Review 28 (2025): 1-8. https://doi.org/10.5603/nmr.103627

Kustić, D., Vukšić, J. and Huić, D. (2025) 'The diagnostic yield of non-invasive testing features in cardiac amyloidosis', Nuclear Medicine Review, 28, pp. 1-8. doi: 10.5603/nmr.103627

Kustić D, Vukšić J, Huić D. The diagnostic yield of non-invasive testing features in cardiac amyloidosis. Nuclear Medicine Review [Internet]. 2025 March 10 [cited 2025 April 11];28:1-8. doi: 10.5603/nmr.103627

D. Kustić, J. Vukšić and D. Huić, "The diagnostic yield of non-invasive testing features in cardiac amyloidosis", Nuclear Medicine Review, vol. 28, pp. 1-8, March 2025. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:252353. [Accessed: 11 April 2025]

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Metadata
Title (english)The diagnostic yield of non-invasive testing features in cardiac amyloidosis
AuthorDomagoj Kustić
AuthorJosipa Vukšić
AuthorDražen Huić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Nuclear Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Nuclear Medicine
Abstract (english)
Background: Cardiac amyloidosis (CA) is a progressive disease in which amyloid fibrils infiltrate the heart muscle. This study aimed to identify features from cardiac biomarkers, electrocardiography (ECG), and echocardiography that may distinguish between transthyretin amyloidosis (ATTR) scintigraphy-positive and negative patients. Material and methods: Seventy-eight consecutive patients, median age 69 years (range 34–81), with suspected CA, negative serum free light chains, and negative serum... More and urine protein electrophoresis with immunofixation, referred to cardiac scintigraphy between 2021 and 2024, were retrospectively enrolled. Cardiac uptake was assessed by Perugini grades. Troponin T, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and various ECG and echocardiographic features were compared between ATTR scintigraphy-positive and negative participants using the t-test, Mann–Whitney U-test, and χ2-test as appropriate. Multivariable stepwise logistic regression created the prediction model for ATTR-positive scintigraphy. The significance level was 0.05. Results: Scintigraphy was ATTR-positive in 24 participants (30.77%). The variables significantly connected with ATTR-positive testing were atrial fibrillation (p = 0.010), first- or second-degree atrioventricular block (p = 0.041), left ventricle (LV) end-diastolic dimension (p = 0.018), LV global longitudinal strain (GLS) (p = 0.040), a restrictive transmitral inflow pattern (p = 0.025), LV posterior wall thickness (p < 0.001), interventricular septum (IVS) thickness (p < 0.001), QRS voltages (p < 0.001), the pseudo-infarct pattern (p < 0.001), and relative apical sparing of the GLS ratio (p < 0.001). The latter four were incorporated into the prediction model for ATTR-positive scintigraphy. Conclusions: ECG and echocardiography remain the essential diagnostic procedures that raise the suspicion of CA and trigger further diagnostics. Low QRS voltages, the pseudo-infarct pattern, IVS thickness, and relative apical sparing of the GLS ratio are sensitive predictors of ATTR-positive scintigraphy findings. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleNuclear Medicine Review
Numberingvol. 28, no. 0, pp. 1-8
p-ISSN1506-9680
e-ISSN1644-4345
DOIhttps://doi.org/10.5603/nmr.103627
URN:NBNurn:nbn:hr:184:252353
Publication2025-03-10
Document URLhttps://journals.viamedica.pl/nuclear_medicine_review/article/view/103627
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2025-03-28 08:15:14
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