prikaz prve stranice dokumenta Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study
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Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study
Journal of Clinical Medicine, 13 (2024), 24; 7665. https://doi.org/10.3390/jcm13247665
Klarica Gembić, Tihana; Grebić, Damir; Gulić, Tamara; Golemac, Mijo; Avirović, Manuela

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Klarica Gembić, T., Grebić, D., Gulić, T., Golemac, M. i Avirović, M. (2024). Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study. Journal of Clinical Medicine, 13. (24). doi: 10.3390/jcm13247665

Klarica Gembić, Tihana, et al. "Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study." Journal of Clinical Medicine, vol. 13, br. 24, 2024. https://doi.org/10.3390/jcm13247665

Klarica Gembić, Tihana, Damir Grebić, Tamara Gulić, Mijo Golemac i Manuela Avirović. "Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study." Journal of Clinical Medicine 13, br. 24 (2024). https://doi.org/10.3390/jcm13247665

Klarica Gembić, T., et al. (2024) 'Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study', Journal of Clinical Medicine, 13(24). doi: 10.3390/jcm13247665

Klarica Gembić T, Grebić D, Gulić T, Golemac M, Avirović M. Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study. Journal of Clinical Medicine [Internet]. 16.12.2024. [pristupljeno 22.01.2025.];13(24). doi: 10.3390/jcm13247665

T. Klarica Gembić, D. Grebić, T. Gulić, M. Golemac i M. Avirović, "Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study", Journal of Clinical Medicine, vol. 13, br. 24, Prosinac 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:696371. [Citirano: 22.01.2025.]

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Podaci o radu
Naslov (engleski)Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study
AutorTihana Klarica Gembić
AutorDamir Grebić
AutorTamara Gulić
AutorMijo Golemac
AutorManuela Avirović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za kirurgiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za nuklearnu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za onkologiju i radioterapiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Kirurgija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Onkologija
Sažetak (engleski)
Objectives: In this paper, we investigate the association of glycoprotein 96 (GP96) and androgen receptor (AR) expression with clinicopathological factors, additional axillary lymph node burden, and their potential role in predicting 5-year overall survival (OS) and disease-free survival (DFS) in breast cancer (BC) patients with sentinel lymph node (SLN) involvement. We also explore the prognostic value of the presence of extranodal extension (ENE) in SLN. Methods: We retrospectively enrolled 107 female patients with cT1-T2 invasive BC and positive SLN biopsy. GP96 and AR expression were immunohistochemically evaluated on tissue microarrays constructed from two 2 mm diameter cores of formalin-fixed paraffin-embedded tumor tissues from each patient. ENE in SLN was measured in the highest (HD-ENE) and widest diameter (WD-ENE). Relative GP96 gene expression was determined using real-time quantitative PCR. Results: The analysis revealed ENE in SLN as the strongest predictive factor for non-SLN metastases. Patients with WD-ENE > HD-ENE had a higher risk of non-SLN metastases and worse DFS compared to those with WD-ENE ≤ HD-ENE. High GP96 expression was associated with a greater relative risk for locoregional recurrence but showed no significant impact on OS or DFS. Histological grade 3, extensive intraductal component (EIC), higher lymph node ratio (LNR), and negative AR were associated with worse DFS, while age, histological grade 3, EIC, and higher LNR were independent predictors of OS. GP96 mRNA levels were elevated in BC tissue compared to normal breast tissue. Conclusions: ENE in SLN is the strongest predictor of non-SLN involvement and could also have prognostic significance. While GP96 expression does not influence survival outcomes, AR expression could be used as a valuable biomarker in the follow-up of BC patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Clinical Medicine
Brojčani podacivol. 13, br. 24, 7665
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm13247665
URN:NBNurn:nbn:hr:184:696371
Datum objave publikacije2024-12-16
ProjektŠifra: uniri-iskusni-prirod-23-93
Naziv (hrvatski): Metalotionein kao potencijalno novi prediktivni čimbenik karcinoma dojke
Naziv (engleski): Metalothionein as a new potential predictive marker of breast cancer
Voditelj: Damir Grebić
Pravna nadležnost: Hrvatska
Financijer: Sveučilište u Rijeci
Linija financiranja: Sveučilište u Rijeci
URL dokumentahttps://www.mdpi.com/2077-0383/13/24/7665
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Bez prerada 4.0 međunarodna (CC BY-ND 4.0)
Datum i vrijeme pohrane2024-12-18 07:18:30