prikaz prve stranice dokumenta Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study
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Scientific paper - Original scientific paper
Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study
Journal of Clinical Medicine, 13 (2024), 24; 7665. https://doi.org/10.3390/jcm13247665
Klarica Gembić, Tihana; Grebić, Damir; Gulić, Tamara; Golemac, Mijo; Avirović, Manuela

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Klarica Gembić, T., Grebić, D., Gulić, T., Golemac, M. & Avirović, M. (2024). Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study. Journal of Clinical Medicine, 13. (24). doi: 10.3390/jcm13247665

Klarica Gembić, Tihana, et al. "Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study." Journal of Clinical Medicine, vol. 13, no. 24, 2024. https://doi.org/10.3390/jcm13247665

Klarica Gembić, Tihana, Damir Grebić, Tamara Gulić, Mijo Golemac and Manuela Avirović. "Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study." Journal of Clinical Medicine 13, no. 24 (2024). https://doi.org/10.3390/jcm13247665

Klarica Gembić, T., et al. (2024) 'Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study', Journal of Clinical Medicine, 13(24). doi: 10.3390/jcm13247665

Klarica Gembić T, Grebić D, Gulić T, Golemac M, Avirović M. Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study. Journal of Clinical Medicine [Internet]. 2024 December 16 [cited 2024 December 18];13(24). doi: 10.3390/jcm13247665

T. Klarica Gembić, D. Grebić, T. Gulić, M. Golemac and M. Avirović, "Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study", Journal of Clinical Medicine, vol. 13, no. 24, December 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:696371. [Accessed: 18 December 2024]

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Metadata
Title (english)Predictive and Prognostic Values of Glycoprotein 96, Androgen Receptors, and Extranodal Extension in Sentinel Lymph Node-Positive Breast Cancer: An Immunohistochemical Retrospective Study
AuthorTihana Klarica Gembić
AuthorDamir Grebić
AuthorTamara Gulić
AuthorMijo Golemac
AuthorManuela Avirović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Surgery)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Nuclear Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Oncology and Radiotherapy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Oncology
Abstract (english)
Objectives: In this paper, we investigate the association of glycoprotein 96 (GP96) and androgen receptor (AR) expression with clinicopathological factors, additional axillary lymph node burden, and their potential role in predicting 5-year overall survival (OS) and disease-free survival (DFS) in breast cancer (BC) patients with sentinel lymph node (SLN) involvement. We also explore the prognostic value of the presence of extranodal extension (ENE) in SLN. Methods: We retrospectively enrolled 107 female patients with cT1-T2 invasive BC and positive SLN biopsy. GP96 and AR expression were immunohistochemically evaluated on tissue microarrays constructed from two 2 mm diameter cores of formalin-fixed paraffin-embedded tumor tissues from each patient. ENE in SLN was measured in the highest (HD-ENE) and widest diameter (WD-ENE). Relative GP96 gene expression was determined using real-time quantitative PCR. Results: The analysis revealed ENE in SLN as the strongest predictive factor for non-SLN metastases. Patients with WD-ENE > HD-ENE had a higher risk of non-SLN metastases and worse DFS compared to those with WD-ENE ≤ HD-ENE. High GP96 expression was associated with a greater relative risk for locoregional recurrence but showed no significant impact on OS or DFS. Histological grade 3, extensive intraductal component (EIC), higher lymph node ratio (LNR), and negative AR were associated with worse DFS, while age, histological grade 3, EIC, and higher LNR were independent predictors of OS. GP96 mRNA levels were elevated in BC tissue compared to normal breast tissue. Conclusions: ENE in SLN is the strongest predictor of non-SLN involvement and could also have prognostic significance. While GP96 expression does not influence survival outcomes, AR expression could be used as a valuable biomarker in the follow-up of BC patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Clinical Medicine
Numberingvol. 13, no. 24, 7665
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm13247665
URN:NBNurn:nbn:hr:184:696371
Publication2024-12-16
ProjectNumber: uniri-iskusni-prirod-23-93
Title (croatian): Metalotionein kao potencijalno novi prediktivni čimbenik karcinoma dojke
Title (english): Metalothionein as a new potential predictive marker of breast cancer
Leader: Damir Grebić
Jurisdiction: Croatia
Funding stream: Sveučilište u Rijeci
Document URLhttps://www.mdpi.com/2077-0383/13/24/7665
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2024-12-18 07:18:30