prikaz prve stranice dokumenta Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny
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Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny
Pathogens, 13 (2024), 12; 1108. https://doi.org/10.3390/pathogens13121108
Krstanović, Fran; Mihalić, Andrea; Šakota, Lucija; Lisnić, Berislav; Jonjić, Stipan; Brizić, Ilija

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Krstanović, F., Mihalić, A., Šakota, L., Lisnić, B., Jonjić, S. i Brizić, I. (2024). Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny. Pathogens, 13. (12). doi: 10.3390/pathogens13121108

Krstanović, Fran, et al. "Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny." Pathogens, vol. 13, br. 12, 2024. https://doi.org/10.3390/pathogens13121108

Krstanović, Fran, Andrea Mihalić, Lucija Šakota, Berislav Lisnić, Stipan Jonjić i Ilija Brizić. "Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny." Pathogens 13, br. 12 (2024). https://doi.org/10.3390/pathogens13121108

Krstanović, F., et al. (2024) 'Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny', Pathogens, 13(12). doi: 10.3390/pathogens13121108

Krstanović F, Mihalić A, Šakota L, Lisnić B, Jonjić S, Brizić I. Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny. Pathogens [Internet]. 14.12.2024. [pristupljeno 17.12.2024.];13(12). doi: 10.3390/pathogens13121108

F. Krstanović, A. Mihalić, L. Šakota, B. Lisnić, S. Jonjić i I. Brizić, "Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny", Pathogens, vol. 13, br. 12, Prosinac 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:474691. [Citirano: 17.12.2024.]

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Podaci o radu
Naslov (engleski)Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny
AutorFran Krstanović
AutorAndrea Mihalić
AutorLucija Šakota
AutorBerislav Lisnić
AutorStipan Jonjić
AutorIlija Brizić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Human cytomegalovirus (HCMV) rarely infects the brain following infection of adult individuals. However, the virus readily infects the brain during congenital HCMV (cHCMV) infection, frequently causing severe neurodevelopmental and neurological sequelae. Interestingly, although the incidence of cHCMV infection is 0.5–1%, the proportion of congenitally infected individuals in which the virus manages to gain access to the brain is unknown. In this study, we used infection of mice with mouse cytomegalovirus (MCMV), the most commonly used experimental system for modeling HCMV disease in humans, to determine the impact of age on the susceptibility of the brain to cytomegalovirus infection and infection-mediated neuroinflammation. We demonstrate that infection of mice during various stages of neonatal development can lead to CMV neuroinvasion and inflammation. In contrast, MCMV infection does not result in MCMV neuroinvasion and neuroinflammation in weanling and adult mice. The obtained results establish a basis for elucidating the mechanisms of CMV neuroinvasion and the deleterious inflammatory response during ontogeny.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPathogens
Brojčani podacivol. 13, br. 12, 1108
e-ISSN2076-0817
DOIhttps://doi.org/10.3390/pathogens13121108
URN:NBNurn:nbn:hr:184:474691
Datum objave publikacije2024-12-14
ProjektŠifra: PZS-2019-02-7879
Naziv (hrvatski): Biologija citomegalovirusne infekcije u mozgu tijekom razvoja i u latenciji
Naziv (engleski): Biology of cytomegalovirus infection in developing brain and latency
Kratica: CMVbrain
Voditelj: Ilija Brizić
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
ProjektŠifra: KK.01.1.1.01.0006
Naziv (hrvatski): Jačanje kapaciteta CERVIRVAC-a za istraživanja u virusnoj imunologiji i vakcinologiji
Naziv (engleski): Strengthening the capacity of CerVirVac (Croatian Centre of Excellence for Virus Immunology and Vaccines) for research in viral immunology and vaccinology
Voditelj: Stipan Jonjić
Pravna nadležnost: eu
Financijer: Europska unija
Linija financiranja: European Regional Development Fund
ProjektŠifra: IP-2022-10-3371
Naziv (hrvatski): Latentna infekcija citomegalovirusom u središnjem živčanom sustavu
Naziv (engleski): Cytomegalovirus latency in the central nervous system
Kratica: CMV-CNS
Voditelj: Ilija Brizić
Pravna nadležnost: Hrvatska
Financijer: Hrvatska zaklada za znanost
Linija financiranja: Research Projects
ProjektŠifra: uniri-iskusni-biomed-23-231
Naziv (hrvatski): Uloga citokina IL-12 u nadzoru citomegalovirusne infekcije u neuronima
Naziv (engleski): The role of the cytokine IL-12 in the control of cytomegalovirus infection in neurons
Voditelj: Ilija Brizić
Pravna nadležnost: Hrvatska
Financijer: Sveučilište u Rijeci
URL dokumentahttps://www.mdpi.com/2076-0817/13/12/1108
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-12-17 07:34:18