prikaz prve stranice dokumenta Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny
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Scientific paper - Original scientific paper
Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny
Pathogens, 13 (2024), 12; 1108. https://doi.org/10.3390/pathogens13121108
Krstanović, Fran; Mihalić, Andrea; Šakota, Lucija; Lisnić, Berislav; Jonjić, Stipan; Brizić, Ilija

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Krstanović, F., Mihalić, A., Šakota, L., Lisnić, B., Jonjić, S. & Brizić, I. (2024). Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny. Pathogens, 13. (12). doi: 10.3390/pathogens13121108

Krstanović, Fran, et al. "Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny." Pathogens, vol. 13, no. 12, 2024. https://doi.org/10.3390/pathogens13121108

Krstanović, Fran, Andrea Mihalić, Lucija Šakota, Berislav Lisnić, Stipan Jonjić and Ilija Brizić. "Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny." Pathogens 13, no. 12 (2024). https://doi.org/10.3390/pathogens13121108

Krstanović, F., et al. (2024) 'Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny', Pathogens, 13(12). doi: 10.3390/pathogens13121108

Krstanović F, Mihalić A, Šakota L, Lisnić B, Jonjić S, Brizić I. Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny. Pathogens [Internet]. 2024 December 14 [cited 2024 December 17];13(12). doi: 10.3390/pathogens13121108

F. Krstanović, A. Mihalić, L. Šakota, B. Lisnić, S. Jonjić and I. Brizić, "Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny", Pathogens, vol. 13, no. 12, December 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:474691. [Accessed: 17 December 2024]

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Metadata
Title (english)Susceptibility of Mouse Brain to MCMV Infection and Neuroinflammation During Ontogeny
AuthorFran Krstanović
AuthorAndrea Mihalić
AuthorLucija Šakota
AuthorBerislav Lisnić
AuthorStipan Jonjić
AuthorIlija Brizić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Human cytomegalovirus (HCMV) rarely infects the brain following infection of adult individuals. However, the virus readily infects the brain during congenital HCMV (cHCMV) infection, frequently causing severe neurodevelopmental and neurological sequelae. Interestingly, although the incidence of cHCMV infection is 0.5–1%, the proportion of congenitally infected individuals in which the virus manages to gain access to the brain is unknown. In this study, we used infection of mice with mouse cytomegalovirus (MCMV), the most commonly used experimental system for modeling HCMV disease in humans, to determine the impact of age on the susceptibility of the brain to cytomegalovirus infection and infection-mediated neuroinflammation. We demonstrate that infection of mice during various stages of neonatal development can lead to CMV neuroinvasion and inflammation. In contrast, MCMV infection does not result in MCMV neuroinvasion and neuroinflammation in weanling and adult mice. The obtained results establish a basis for elucidating the mechanisms of CMV neuroinvasion and the deleterious inflammatory response during ontogeny.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePathogens
Numberingvol. 13, no. 12, 1108
e-ISSN2076-0817
DOIhttps://doi.org/10.3390/pathogens13121108
URN:NBNurn:nbn:hr:184:474691
Publication2024-12-14
ProjectNumber: PZS-2019-02-7879
Title (croatian): Biologija citomegalovirusne infekcije u mozgu tijekom razvoja i u latenciji
Title (english): Biology of cytomegalovirus infection in developing brain and latency
Acronym: CMVbrain
Leader: Ilija Brizić
Jurisdiction: Croatia
Funding stream: Research Projects
ProjectNumber: KK.01.1.1.01.0006
Title (croatian): Jačanje kapaciteta CERVIRVAC-a za istraživanja u virusnoj imunologiji i vakcinologiji
Title (english): Strengthening the capacity of CerVirVac (Croatian Centre of Excellence for Virus Immunology and Vaccines) for research in viral immunology and vaccinology
Leader: Stipan Jonjić
Jurisdiction: eu
Funding stream: European Regional Development Fund
ProjectNumber: IP-2022-10-3371
Title (croatian): Latentna infekcija citomegalovirusom u središnjem živčanom sustavu
Title (english): Cytomegalovirus latency in the central nervous system
Acronym: CMV-CNS
Leader: Ilija Brizić
Jurisdiction: Croatia
Funding stream: Research Projects
ProjectNumber: uniri-iskusni-biomed-23-231
Title (croatian): Uloga citokina IL-12 u nadzoru citomegalovirusne infekcije u neuronima
Title (english): The role of the cytokine IL-12 in the control of cytomegalovirus infection in neurons
Leader: Ilija Brizić
Jurisdiction: Croatia
Document URLhttps://www.mdpi.com/2076-0817/13/12/1108
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-12-17 07:34:18