prikaz prve stranice dokumenta Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality
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Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality
Frontiers in Immunology, 14 (2023); 1231782. https://doi.org/10.3389/fimmu.2023.1231782
Khaleafi, Raghad; Železnjak, Jelena; Cordela, Sapir; Drucker, Shani; Roviš, Tihana Lenac; Jonjić, Stipan; Bar-On, Yotam

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Khaleafi, R., Železnjak, J., Cordela, S., Drucker, S., Roviš, T. L., Jonjić, S. i Bar On, Y. (2023). Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality. Frontiers in Immunology, 14.. doi: 10.3389/fimmu.2023.1231782

Khaleafi, Raghad, et al. "Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality." Frontiers in Immunology, vol. 14, 2023. https://doi.org/10.3389/fimmu.2023.1231782

Khaleafi, Raghad, Jelena Železnjak, Sapir Cordela, Shani Drucker, Tihana Lenac Roviš, Stipan Jonjić i Yotam Bar On. "Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality." Frontiers in Immunology 14 (2023). https://doi.org/10.3389/fimmu.2023.1231782

Khaleafi, R., et al. (2023) 'Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality', Frontiers in Immunology, 14. doi: 10.3389/fimmu.2023.1231782

Khaleafi R, Železnjak J, Cordela S, Drucker S, Roviš TL, Jonjić S, i sur.. Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality. Frontiers in Immunology [Internet]. 11.09.2023. [pristupljeno 04.12.2024.];14. doi: 10.3389/fimmu.2023.1231782

R. Khaleafi, et al., "Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality", Frontiers in Immunology, vol. 14, Rujan 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:697068. [Citirano: 04.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:697068
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Podaci o radu
Naslov (engleski)Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality
AutorRaghad Khaleafi
AutorJelena Železnjak
AutorSapir Cordela
AutorShani Drucker
AutorTihana Lenac Roviš
AutorStipan Jonjić
AutorYotam Bar-On
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
In recent years, reoviruses have been of major interest in immunotherapy because of their oncolytic properties. Preclinical and clinical trials, in which reovirus was used for the treatment of melanoma and glioblastoma, have paved the way for future clinical use of reovirus. However, little is known about how reovirus infection affects the tumor microenvironment and immune response towards infected tumor cells. Studies have shown that reovirus can directly stimulate natural killer (NK) cells, but how reovirus affects cellular ligands on tumor cells, which are ultimately key to tumor recognition and elimination by NK cells, has not been investigated. We tested how reovirus infection affects the binding of the NK Group-2 member D (NKG2D) receptor, which is a dominant mediator of NK cell anti-tumor activity. Using models of human-derived melanoma and glioblastoma tumors, we demonstrated that NKG2D ligands are downregulated in tumor cells post-reovirus-infection due to the impaired translation of these ligands in reovirus-infected cells. Moreover, we showed that downregulation of NKG2D ligands significantly impaired the binding of NKG2D to infected tumor cells. We further demonstrated that reduced recognition of NKG2D ligands significantly alters NK cell anti-tumor cytotoxicity in human primary NK cells and in the NK cell line NK-92. Thus, this study provides novel insights into reovirus-host interactions and could lead to the development of novel reovirus-based therapeutics that enhance the anti-tumor immune response.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaFrontiers in Immunology
Brojčani podacivol. 14, 1231782
e-ISSN1664-3224
DOIhttps://doi.org/10.3389/fimmu.2023.1231782
URN:NBNurn:nbn:hr:184:697068
Datum objave publikacije2023-09-11
URL dokumentahttps://www.frontiersin.org/articles/10.3389/fimmu.2023.1231782/full
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-11-12 09:16:02