prikaz prve stranice dokumenta Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality
  Download
PDF 4.31 MB
Scientific paper - Original scientific paper
Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality
Frontiers in Immunology, 14 (2023); 1231782. https://doi.org/10.3389/fimmu.2023.1231782
Khaleafi, Raghad; Železnjak, Jelena; Cordela, Sapir; Drucker, Shani; Roviš, Tihana Lenac; Jonjić, Stipan; Bar-On, Yotam

Cite this document

Khaleafi, R., Železnjak, J., Cordela, S., Drucker, S., Roviš, T. L., Jonjić, S. & Bar On, Y. (2023). Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality. Frontiers in Immunology, 14.. doi: 10.3389/fimmu.2023.1231782

Khaleafi, Raghad, et al. "Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality." Frontiers in Immunology, vol. 14, 2023. https://doi.org/10.3389/fimmu.2023.1231782

Khaleafi, Raghad, Jelena Železnjak, Sapir Cordela, Shani Drucker, Tihana Lenac Roviš, Stipan Jonjić and Yotam Bar On. "Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality." Frontiers in Immunology 14 (2023). https://doi.org/10.3389/fimmu.2023.1231782

Khaleafi, R., et al. (2023) 'Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality', Frontiers in Immunology, 14. doi: 10.3389/fimmu.2023.1231782

Khaleafi R, Železnjak J, Cordela S, Drucker S, Roviš TL, Jonjić S, and sur.. Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality. Frontiers in Immunology [Internet]. 2023 September 11 [cited 2025 January 23];14. doi: 10.3389/fimmu.2023.1231782

R. Khaleafi, et al., "Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality", Frontiers in Immunology, vol. 14, September 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:697068. [Accessed: 23 January 2025]

Please login to the repository to save this object to your list.
Metadata
Title (english)Reovirus infection of tumor cells reduces the expression of NKG2D ligands, leading to impaired NK-cell cytotoxicity and functionality
AuthorRaghad Khaleafi
AuthorJelena Železnjak
AuthorSapir Cordela
AuthorShani Drucker
AuthorTihana Lenac Roviš
AuthorStipan Jonjić
AuthorYotam Bar-On
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
In recent years, reoviruses have been of major interest in immunotherapy because of their oncolytic properties. Preclinical and clinical trials, in which reovirus was used for the treatment of melanoma and glioblastoma, have paved the way for future clinical use of reovirus. However, little is known about how reovirus infection affects the tumor microenvironment and immune response towards infected tumor cells. Studies have shown that reovirus can directly stimulate natural killer (NK) cells, but how reovirus affects cellular ligands on tumor cells, which are ultimately key to tumor recognition and elimination by NK cells, has not been investigated. We tested how reovirus infection affects the binding of the NK Group-2 member D (NKG2D) receptor, which is a dominant mediator of NK cell anti-tumor activity. Using models of human-derived melanoma and glioblastoma tumors, we demonstrated that NKG2D ligands are downregulated in tumor cells post-reovirus-infection due to the impaired translation of these ligands in reovirus-infected cells. Moreover, we showed that downregulation of NKG2D ligands significantly impaired the binding of NKG2D to infected tumor cells. We further demonstrated that reduced recognition of NKG2D ligands significantly alters NK cell anti-tumor cytotoxicity in human primary NK cells and in the NK cell line NK-92. Thus, this study provides novel insights into reovirus-host interactions and could lead to the development of novel reovirus-based therapeutics that enhance the anti-tumor immune response.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleFrontiers in Immunology
Numberingvol. 14, 1231782
e-ISSN1664-3224
DOIhttps://doi.org/10.3389/fimmu.2023.1231782
URN:NBNurn:nbn:hr:184:697068
Publication2023-09-11
Document URLhttps://www.frontiersin.org/articles/10.3389/fimmu.2023.1231782/full
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-11-12 09:16:02