Cancer of the oral cavity and oropharynx ranks among the top ten most common malignancies worldwide and is among the top three in developing countries. It occurs twice as often in men. The main risk factors are the use of tobacco and alcohol products, as well as HPV infection. HPV is particularly noted as a risk factor for oropharyngeal cancers. Some patients develop precancerous lesions, with leukoplakia and erythroplakia being the most common; the latter carries a significantly higher risk of malignant transformation. Oral cavity cancer is clinically easy to diagnose since most tumors present as ulcers with irregular edges. The primary treatment is surgical and involves tumor excision and neck dissection. In advanced stages of the disease, adjuvant radiotherapy is also used. The aim of the research was to present, analyze, and compare general, clinical, and pathohistological data of surgically treated patients at KBC Rijeka over a four-year period (2020-2023). The study includes 34 patients. Data analysis revealed that the majority of patients were male and consumed tobacco products, with half suffering from hypertension. The floor of the mouth and tongue were the most commonly affected sublocations, and four patients had oropharyngeal cancer. All tumors were of squamous cell origin. Approximately one-third of patients were diagnosed with T3 and T4 classified tumors at the time of diagnosis, with the largest proportion of patients being in the fourth stage of the disease. Most patients underwent simultaneous tumor excision and neck dissection, and approximately half received adjuvant radiotherapy.