prikaz prve stranice dokumenta A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction
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A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction
Life, 14 (2024), 5; 575. https://doi.org/10.3390/life14050575
Ledina, Dragan; Ivić, Ivo; Tadin, Ante; Bodulić, Kristian; LeDuc, James W.; Markotić, Alemka

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Ledina, D., Ivić, I., Tadin, A., Bodulić, K., LeDuc, J. W. i Markotić, A. (2024). A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction. Life, 14. (5). doi: 10.3390/life14050575

Ledina, Dragan, et al. "A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction." Life, vol. 14, br. 5, 2024. https://doi.org/10.3390/life14050575

Ledina, Dragan, Ivo Ivić, Ante Tadin, Kristian Bodulić, James W. LeDuc i Alemka Markotić. "A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction." Life 14, br. 5 (2024). https://doi.org/10.3390/life14050575

Ledina, D., et al. (2024) 'A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction', Life, 14(5). doi: 10.3390/life14050575

Ledina D, Ivić I, Tadin A, Bodulić K, LeDuc JW, Markotić A. A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction. Life [Internet]. 30.04.2024. [pristupljeno 07.05.2024.];14(5). doi: 10.3390/life14050575

D. Ledina, I. Ivić, A. Tadin, K. Bodulić, J. W. LeDuc i A. Markotić, "A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction", Life, vol. 14, br. 5, Travanj 2024. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:295493. [Citirano: 07.05.2024.]

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Podaci o radu
Naslov (engleski)A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction
AutorDragan Ledina
AutorIvo Ivić
AutorAnte Tadin
AutorKristian Bodulić
AutorJames W. LeDuc
AutorAlemka Markotić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za zarazne bolesti)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
While the pathology of acute hemorrhagic fever with renal syndrome (HFRS) has been widely researched, details on the chronic HFRS sequelae remain mainly unexplored. In this study, we analyzed the clinical and laboratory characteristics of 30 convalescent HFRS patients 14 years after the disease contraction, mainly emphasizing several endothelial dysfunction parameters. Convalescent HFRS patients exhibited significantly higher serum levels of erythrocyte sedimentation rate, von Willebrand factor, uric acid, C-reactive protein and immunoglobulin A when compared to healthy individuals. Furthermore, 24 h urine analyses revealed significantly lower sodium and potassium urine levels, as well as significantly higher proteinuria, microalbumin levels and β2-microglobulin levels when compared to healthy individuals. First morning urine analysis revealed significantly higher levels of hematuria in convalescent HFRS patients. None of the additional analyzed endothelium dysfunction markers were significantly different in post-HFRS patients and healthy individuals, including serum and urine P-selectin, E-selectin, soluble intercellular adhesion molecule 1, vascular intercellular adhesion molecule 1 (sVCAM-1) and vascular endothelial growth factor (VEGF). However, binary logistic regression revealed a weak association of serum sVCAM-1 and urine VEGF levels with HFRS contraction. Generally, our findings suggest mild chronic inflammation and renal dysfunction levels in convalescent HFRS patients 14 years after the disease contraction.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaLife
Brojčani podacivol. 14, br. 5, 575
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life14050575
URN:NBNurn:nbn:hr:184:295493
Datum objave publikacije2024-04-30
URL dokumentahttps://www.mdpi.com/2075-1729/14/5/575
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2024-05-02 09:05:19