prikaz prve stranice dokumenta A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction
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Scientific paper - Original scientific paper
A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction
Life, 14 (2024), 5; 575. https://doi.org/10.3390/life14050575
Ledina, Dragan; Ivić, Ivo; Tadin, Ante; Bodulić, Kristian; LeDuc, James W.; Markotić, Alemka

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Ledina, D., Ivić, I., Tadin, A., Bodulić, K., LeDuc, J. W. & Markotić, A. (2024). A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction. Life, 14. (5). doi: 10.3390/life14050575

Ledina, Dragan, et al. "A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction." Life, vol. 14, no. 5, 2024. https://doi.org/10.3390/life14050575

Ledina, Dragan, Ivo Ivić, Ante Tadin, Kristian Bodulić, James W. LeDuc and Alemka Markotić. "A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction." Life 14, no. 5 (2024). https://doi.org/10.3390/life14050575

Ledina, D., et al. (2024) 'A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction', Life, 14(5). doi: 10.3390/life14050575

Ledina D, Ivić I, Tadin A, Bodulić K, LeDuc JW, Markotić A. A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction. Life [Internet]. 2024 April 30 [cited 2025 March 04];14(5). doi: 10.3390/life14050575

D. Ledina, I. Ivić, A. Tadin, K. Bodulić, J. W. LeDuc and A. Markotić, "A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction", Life, vol. 14, no. 5, April 2024. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:295493. [Accessed: 04 March 2025]

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Metadata
Title (english)A Comprehensive Analysis of Renal and Endothelium Dysfunction Markers Fourteen Years after Hemorrhagic Fever with Renal Syndrome Contraction
AuthorDragan Ledina
AuthorIvo Ivić
AuthorAnte Tadin
AuthorKristian Bodulić
AuthorJames W. LeDuc
AuthorAlemka Markotić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Infectious Diseases)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
While the pathology of acute hemorrhagic fever with renal syndrome (HFRS) has been widely researched, details on the chronic HFRS sequelae remain mainly unexplored. In this study, we analyzed the clinical and laboratory characteristics of 30 convalescent HFRS patients 14 years after the disease contraction, mainly emphasizing several endothelial dysfunction parameters. Convalescent HFRS patients exhibited significantly higher serum levels of erythrocyte sedimentation rate, von Willebrand factor, uric acid, C-reactive protein and immunoglobulin A when compared to healthy individuals. Furthermore, 24 h urine analyses revealed significantly lower sodium and potassium urine levels, as well as significantly higher proteinuria, microalbumin levels and β2-microglobulin levels when compared to healthy individuals. First morning urine analysis revealed significantly higher levels of hematuria in convalescent HFRS patients. None of the additional analyzed endothelium dysfunction markers were significantly different in post-HFRS patients and healthy individuals, including serum and urine P-selectin, E-selectin, soluble intercellular adhesion molecule 1, vascular intercellular adhesion molecule 1 (sVCAM-1) and vascular endothelial growth factor (VEGF). However, binary logistic regression revealed a weak association of serum sVCAM-1 and urine VEGF levels with HFRS contraction. Generally, our findings suggest mild chronic inflammation and renal dysfunction levels in convalescent HFRS patients 14 years after the disease contraction.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleLife
Numberingvol. 14, no. 5, 575
e-ISSN2075-1729
DOIhttps://doi.org/10.3390/life14050575
URN:NBNurn:nbn:hr:184:295493
Publication2024-04-30
Document URLhttps://www.mdpi.com/2075-1729/14/5/575
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2024-05-02 09:05:19