prikaz prve stranice dokumenta Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion
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Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion
eLife, 10 (2021); 59350. https://doi.org/10.7554/eLife.59350
Angulo, Guillem; Železnjak, Jelena; Martínez-Vicente, Pablo; Puñet-Ortiz, Joan; Hengel, Hartmut; Messerle, Martin; Oxenius, Annette; Jonjić, Stipan; Krmpotić, Astrid; Engel, Pablo; Angulo, Ana

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Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion | Rad u časopisu / Znanstveni rad - Izvorni znanstveni rad
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Angulo, G., Železnjak, J., Martínez Vicente, P., Puñet Ortiz, J., Hengel, H., Messerle, M. ... Angulo, A. (2021). Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion. eLife, 10.. doi: 10.7554/eLife.59350

Angulo, Guillem, et al. "Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion." eLife, vol. 10, 2021. https://doi.org/10.7554/eLife.59350

Angulo, Guillem, Jelena Železnjak, Pablo Martínez Vicente, Joan Puñet Ortiz, Hartmut Hengel, Martin Messerle, Annette Oxenius, et al. "Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion." eLife 10 (2021). https://doi.org/10.7554/eLife.59350

Angulo, G., et al. (2021) 'Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion', eLife, 10. doi: 10.7554/eLife.59350

Angulo G, Železnjak J, Martínez Vicente P, Puñet Ortiz J, Hengel H, Messerle M, i sur.. Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion. eLife [Internet]. 18.01.2021. [pristupljeno 24.12.2024.];10. doi: 10.7554/eLife.59350

G. Angulo, et al., "Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion", eLife, vol. 10, Siječanj 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:255173. [Citirano: 24.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:255173
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Naslov (engleski)Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion
AutorGuillem Angulo
AutorJelena Železnjak
AutorPablo Martínez-Vicente
AutorJoan Puñet-Ortiz
AutorHartmut Hengel
AutorMartin Messerle
AutorAnnette Oxenius
AutorStipan Jonjić
AutorAstrid Krmpotić
AutorPablo Engel
AutorAna Angulo
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Viral infections are controlled, and very often cleared, by activated T lymphocytes. The inducible co-stimulator (ICOS) mediates its functions by binding to its ligand ICOSL, enhancing T-cell activation and optimal germinal center (GC) formation. Here, we show that ICOSL is heavily downmodulated during infection of antigen-presenting cells by different herpesviruses. We found that, in murine cytomegalovirus (MCMV), the immunoevasin m138/fcr-1 physically interacts with ICOSL, impeding its maturation and promoting its lysosomal degradation. This viral protein counteracts T-cell responses, in an ICOS-dependent manner, and limits virus control during the acute MCMV infection. Additionally, we report that blockade of ICOSL in MCMV-infected mice critically regulates the production of MCMV-specific antibodies due to a reduction of T follicular helper and GC B cells. Altogether, these findings reveal a novel mechanism evolved by MCMV to counteract adaptive immune surveillance, and demonstrates a role of the ICOS:ICOSL axis in the host defense against herpesviruses.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaeLife
Brojčani podacivol. 10, 59350
e-ISSN2050-084X
DOIhttps://doi.org/10.7554/eLife.59350
URN:NBNurn:nbn:hr:184:255173
Datum objave publikacije2021-01-18
ProjektŠifra: uniri-biomed-18-170
Naziv (hrvatski): Izbjegavanje imunosnog nadzora posredovanog receptorom NCR1 od strane mišjeg citomegalovirusa
Naziv (engleski): Mouse cytomegalovirus evasion of NCR1 mediated immune control
Voditelj: Astrid Krmpotić
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Nema
ProjektŠifra: KK.011.1.01.0006
Naziv (engleski): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Voditelj: Stipan Jonjić
Pravna nadležnost: eu
Financijer: ERDF
Linija financiranja: kompetitivno projektno financiranje
ProjektŠifra: N/A
Naziv (hrvatski): Centar izvrsnosti za virusnu imunologiju i cjepiva
Naziv (engleski): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Kratica: CERVirVac
Voditelj: Stipan Jonjić
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZCI
URL dokumentahttps://elifesciences.org/articles/59350
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
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Datum i vrijeme pohrane2024-01-31 07:25:30