prikaz prve stranice dokumenta Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion
  Download
PDF 3.27 MB
Scientific paper - Original scientific paper
Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion
eLife, 10 (2021); 59350. https://doi.org/10.7554/eLife.59350
Angulo, Guillem; Železnjak, Jelena; Martínez-Vicente, Pablo; Puñet-Ortiz, Joan; Hengel, Hartmut; Messerle, Martin; Oxenius, Annette; Jonjić, Stipan; Krmpotić, Astrid; Engel, Pablo; Angulo, Ana

Linked objects
Cytomegalovirus restricts ICOSL expression on antigen presenting cells disabling T cell co-stimulation and contributing to immune evasion | Paper published in journal / Scientific paper - Original scientific paper
Cite this document

Angulo, G., Železnjak, J., Martínez Vicente, P., Puñet Ortiz, J., Hengel, H., Messerle, M. ... Angulo, A. (2021). Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion. eLife, 10.. doi: 10.7554/eLife.59350

Angulo, Guillem, et al. "Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion." eLife, vol. 10, 2021. https://doi.org/10.7554/eLife.59350

Angulo, Guillem, Jelena Železnjak, Pablo Martínez Vicente, Joan Puñet Ortiz, Hartmut Hengel, Martin Messerle, Annette Oxenius, et al. "Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion." eLife 10 (2021). https://doi.org/10.7554/eLife.59350

Angulo, G., et al. (2021) 'Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion', eLife, 10. doi: 10.7554/eLife.59350

Angulo G, Železnjak J, Martínez Vicente P, Puñet Ortiz J, Hengel H, Messerle M, and sur.. Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion. eLife [Internet]. 2021 January 18 [cited 2024 November 19];10. doi: 10.7554/eLife.59350

G. Angulo, et al., "Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion", eLife, vol. 10, January 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:255173. [Accessed: 19 November 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion
AuthorGuillem Angulo
AuthorJelena Železnjak
AuthorPablo Martínez-Vicente
AuthorJoan Puñet-Ortiz
AuthorHartmut Hengel
AuthorMartin Messerle
AuthorAnnette Oxenius
AuthorStipan Jonjić
AuthorAstrid Krmpotić
AuthorPablo Engel
AuthorAna Angulo
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Viral infections are controlled, and very often cleared, by activated T lymphocytes. The inducible co-stimulator (ICOS) mediates its functions by binding to its ligand ICOSL, enhancing T-cell activation and optimal germinal center (GC) formation. Here, we show that ICOSL is heavily downmodulated during infection of antigen-presenting cells by different herpesviruses. We found that, in murine cytomegalovirus (MCMV), the immunoevasin m138/fcr-1 physically interacts with ICOSL, impeding its maturation and promoting its lysosomal degradation. This viral protein counteracts T-cell responses, in an ICOS-dependent manner, and limits virus control during the acute MCMV infection. Additionally, we report that blockade of ICOSL in MCMV-infected mice critically regulates the production of MCMV-specific antibodies due to a reduction of T follicular helper and GC B cells. Altogether, these findings reveal a novel mechanism evolved by MCMV to counteract adaptive immune surveillance, and demonstrates a role of the ICOS:ICOSL axis in the host defense against herpesviruses.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleeLife
Numberingvol. 10, 59350
e-ISSN2050-084X
DOIhttps://doi.org/10.7554/eLife.59350
URN:NBNurn:nbn:hr:184:255173
Publication2021-01-18
ProjectNumber: uniri-biomed-18-170
Title (croatian): Izbjegavanje imunosnog nadzora posredovanog receptorom NCR1 od strane mišjeg citomegalovirusa
Title (english): Mouse cytomegalovirus evasion of NCR1 mediated immune control
Leader: Astrid Krmpotić
Jurisdiction: Croatia
Funding stream: Nema
ProjectNumber: KK.011.1.01.0006
Title (english): Jačanje kapaciteta CerVirVac-a za istraživanja u virusnoj imunologiji i vakcinologiji
Leader: Stipan Jonjić
Jurisdiction: eu
Funding stream: kompetitivno projektno financiranje
ProjectNumber: N/A
Title (croatian): Centar izvrsnosti za virusnu imunologiju i cjepiva
Title (english): Centre of Excellence for Research in Viral Immunology and the Development of New Vaccines
Acronym: CERVirVac
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZCI
Document URLhttps://elifesciences.org/articles/59350
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-01-31 07:25:30