prikaz prve stranice dokumenta Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia
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Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia
British Journal of Haematology, 193 (2021), 6; 1157-1171. https://doi.org/10.1111/bjh.17330
Dander, Erica; Fallati, Alessandra; Gulić, Tamara; Pagni, Fabio; Gaspari, Stefania; Silvestri, Daniela; Cricrì, Giulia; Bedini, Gloria; Portale, Federica; Buracchi, Chiara; Starace, Rita; Pasqualini, Fabio; D'Angiò, Mariella; Brizzolara, Lisa; Maglia, Oscar; Mantovani, Alberto; Garlanda, Cecilia; Valsecchi, Maria Grazia; Locatelli, Franco; Biondi, Andrea; Bottazzi, Barbara; Allavena, Paola; D'Amico, Giovanna Više autora...

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Dander, E., Fallati, A., Gulić, T., Pagni, F., Gaspari, S., Silvestri, D. ... D'Amico, G. (2021). Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia. British Journal of Haematology, 193. (6), 1157-1171. doi: 10.1111/bjh.17330

Dander, Erica, et al. "Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia." British Journal of Haematology, vol. 193, br. 6, 2021, str. 1157-1171. https://doi.org/10.1111/bjh.17330

Dander, Erica, Alessandra Fallati, Tamara Gulić, Fabio Pagni, Stefania Gaspari, Daniela Silvestri, Giulia Cricrì, et al. "Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia." British Journal of Haematology 193, br. 6 (2021): 1157-1171. https://doi.org/10.1111/bjh.17330

Dander, E., et al. (2021) 'Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia', British Journal of Haematology, 193(6), str. 1157-1171. doi: 10.1111/bjh.17330

Dander E, Fallati A, Gulić T, Pagni F, Gaspari S, Silvestri D, i sur.. Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia. British Journal of Haematology [Internet]. 13.03.2021. [pristupljeno 05.05.2024.];193(6):1157-1171. doi: 10.1111/bjh.17330

E. Dander, et al., "Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia", British Journal of Haematology, vol. 193, br. 6, str. 1157-1171, Ožujak 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:528320. [Citirano: 05.05.2024.]

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Naslov (engleski)Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia
AutorErica Dander
AutorAlessandra Fallati
AutorTamara Gulić
AutorFabio Pagni
AutorStefania Gaspari
AutorDaniela Silvestri
AutorGiulia Cricrì
AutorGloria Bedini
AutorFederica Portale
AutorChiara Buracchi
AutorRita Starace
AutorFabio Pasqualini
AutorMariella D'Angiò
AutorLisa Brizzolara
AutorOscar Maglia
AutorAlberto Mantovani
AutorCecilia Garlanda
AutorMaria Grazia Valsecchi
AutorFranco Locatelli
AutorAndrea Biondi
AutorBarbara Bottazzi
AutorPaola Allavena
AutorGiovanna D'Amico
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Sažetak (engleski)
Summary B‐cell acute lymphoblastic leukaemia (B‐ALL) reprograms the surrounding bone marrow (BM) stroma to create a leukaemia‐supportive niche. To elucidate the contribution of immune cells to the leukaemic microenvironment, we investigated the involvement of monocyte/macrophage compartments, as well as several recruitment pathways in B‐ALL development. Immunohistochemistry analyses showed that CD68‐expressing macrophages were increased in leukaemic BM biopsies, compared to controls and predominantly expressed the M2‐like markers CD163 and CD206. Furthermore, the "non‐classical" CD14 CD16 monocyte subset, expressing high CX3CR1 levels, was significantly increased in B‐ALL patients' peripheral blood. CX3CL1 was shown to be significantly upregulated in leukaemic BM plasma, thus providing an altered migratory pathway possibly guiding NC monocyte recruitment into the BM. Additionally, the monocyte/macrophage chemoattractant chemokine ligand 2 (CCL2) strongly increased in leukaemic BM plasma, possibly because of the interaction of leukaemic cells with mesenchymal stromal cells and vascular cells and due to a stimulatory effect of leukaemia‐related inflammatory mediators. C5a, a macrophage chemoattractant and M2‐polarizing factor, further appeared to be upregulated in the leukaemic BM, possibly as an effect of PTX3 decrease, that could unleash complement cascade activation. Overall, deregulated monocyte/macrophage compartments are part of the extensive BM microenvironment remodelling at B‐ALL diagnosis and could represent valuable targets for novel treatments to be coupled with classical chemotherapy.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBritish Journal of Haematology
Brojčani podacivol. 193, br. 6, str. 1157-1171
p-ISSN0007-1048
e-ISSN1365-2141
DOIhttps://doi.org/10.1111/bjh.17330
URN:NBNurn:nbn:hr:184:528320
Datum objave publikacije2021-03-13
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1111/bjh.17330
Vrsta resursaTekst
Prava pristupaOgraničen pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-09-18 10:17:15