prikaz prve stranice dokumenta Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia
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Scientific paper - Original scientific paper
Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia
British Journal of Haematology, 193 (2021), 6; 1157-1171. https://doi.org/10.1111/bjh.17330
Dander, Erica; Fallati, Alessandra; Gulić, Tamara; Pagni, Fabio; Gaspari, Stefania; Silvestri, Daniela; Cricrì, Giulia; Bedini, Gloria; Portale, Federica; Buracchi, Chiara; Starace, Rita; Pasqualini, Fabio; D'Angiò, Mariella; Brizzolara, Lisa; Maglia, Oscar; Mantovani, Alberto; Garlanda, Cecilia; Valsecchi, Maria Grazia; Locatelli, Franco; Biondi, Andrea; Bottazzi, Barbara; Allavena, Paola; D'Amico, Giovanna More authors...

Cite this document

Dander, E., Fallati, A., Gulić, T., Pagni, F., Gaspari, S., Silvestri, D. ... D'Amico, G. (2021). Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia. British Journal of Haematology, 193. (6), 1157-1171. doi: 10.1111/bjh.17330

Dander, Erica, et al. "Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia." British Journal of Haematology, vol. 193, no. 6, 2021, pp. 1157-1171. https://doi.org/10.1111/bjh.17330

Dander, Erica, Alessandra Fallati, Tamara Gulić, Fabio Pagni, Stefania Gaspari, Daniela Silvestri, Giulia Cricrì, et al. "Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia." British Journal of Haematology 193, no. 6 (2021): 1157-1171. https://doi.org/10.1111/bjh.17330

Dander, E., et al. (2021) 'Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia', British Journal of Haematology, 193(6), pp. 1157-1171. doi: 10.1111/bjh.17330

Dander E, Fallati A, Gulić T, Pagni F, Gaspari S, Silvestri D, and sur.. Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia. British Journal of Haematology [Internet]. 2021 March 13 [cited 2024 December 27];193(6):1157-1171. doi: 10.1111/bjh.17330

E. Dander, et al., "Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia", British Journal of Haematology, vol. 193, no. 6, pp. 1157-1171, March 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:528320. [Accessed: 27 December 2024]

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Metadata
Title (english)Monocyte–macrophage polarization and recruitment pathways in the tumour microenvironment of B‐cell acute lymphoblastic leukaemia
AuthorErica Dander
AuthorAlessandra Fallati
AuthorTamara Gulić
AuthorFabio Pagni
AuthorStefania Gaspari
AuthorDaniela Silvestri
AuthorGiulia Cricrì
AuthorGloria Bedini
AuthorFederica Portale
AuthorChiara Buracchi
AuthorRita Starace
AuthorFabio Pasqualini
AuthorMariella D'Angiò
AuthorLisa Brizzolara
AuthorOscar Maglia
AuthorAlberto Mantovani
AuthorCecilia Garlanda
AuthorMaria Grazia Valsecchi
AuthorFranco Locatelli
AuthorAndrea Biondi
AuthorBarbara Bottazzi
AuthorPaola Allavena
AuthorGiovanna D'Amico
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Immunology
Abstract (english)
Summary B‐cell acute lymphoblastic leukaemia (B‐ALL) reprograms the surrounding bone marrow (BM) stroma to create a leukaemia‐supportive niche. To elucidate the contribution of immune cells to the leukaemic microenvironment, we investigated the involvement of monocyte/macrophage compartments, as well as several recruitment pathways in B‐ALL development. Immunohistochemistry analyses showed that CD68‐expressing macrophages were increased in leukaemic BM biopsies, compared to controls and predominantly expressed the M2‐like markers CD163 and CD206. Furthermore, the "non‐classical" CD14 CD16 monocyte subset, expressing high CX3CR1 levels, was significantly increased in B‐ALL patients' peripheral blood. CX3CL1 was shown to be significantly upregulated in leukaemic BM plasma, thus providing an altered migratory pathway possibly guiding NC monocyte recruitment into the BM. Additionally, the monocyte/macrophage chemoattractant chemokine ligand 2 (CCL2) strongly increased in leukaemic BM plasma, possibly because of the interaction of leukaemic cells with mesenchymal stromal cells and vascular cells and due to a stimulatory effect of leukaemia‐related inflammatory mediators. C5a, a macrophage chemoattractant and M2‐polarizing factor, further appeared to be upregulated in the leukaemic BM, possibly as an effect of PTX3 decrease, that could unleash complement cascade activation. Overall, deregulated monocyte/macrophage compartments are part of the extensive BM microenvironment remodelling at B‐ALL diagnosis and could represent valuable targets for novel treatments to be coupled with classical chemotherapy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBritish Journal of Haematology
Numberingvol. 193, no. 6, pp. 1157-1171
p-ISSN0007-1048
e-ISSN1365-2141
DOIhttps://doi.org/10.1111/bjh.17330
URN:NBNurn:nbn:hr:184:528320
Publication2021-03-13
Document URLhttps://onlinelibrary.wiley.com/doi/10.1111/bjh.17330
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2023-09-18 10:17:15