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Importance of Cellular Immunity and IFN-γ Concentration in Preventing SARS-CoV-2 Infection and Reinfection: A Cohort Study
Viruses, 15 (2023), 3; 792. https://doi.org/10.3390/v15030792
Primorac, Dragan; Brlek, Petar; Pavelić, Eduard Stjepan; Mešić, Jana; Glavaš Weinberger, David; Matišić, Vid; Molnar, Vilim; Srića, Saša; Zadro, Renata

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Primorac, D., Brlek, P., Pavelić, E. S., Mešić, J., Glavaš Weinberger, D., Matišić, V. ... Zadro, R. (2023). Importance of Cellular Immunity and IFN-γ Concentration in Preventing SARS-CoV-2 Infection and Reinfection: A Cohort Study. Viruses, 15. (3). doi: 10.3390/v15030792

Primorac, Dragan, et al. "Importance of Cellular Immunity and IFN-γ Concentration in Preventing SARS-CoV-2 Infection and Reinfection: A Cohort Study." Viruses, vol. 15, br. 3, 2023. https://doi.org/10.3390/v15030792

Primorac, Dragan, Petar Brlek, Eduard Stjepan Pavelić, Jana Mešić, David Glavaš Weinberger, Vid Matišić, Vilim Molnar, Saša Srića i Renata Zadro. "Importance of Cellular Immunity and IFN-γ Concentration in Preventing SARS-CoV-2 Infection and Reinfection: A Cohort Study." Viruses 15, br. 3 (2023). https://doi.org/10.3390/v15030792

Primorac, D., et al. (2023) 'Importance of Cellular Immunity and IFN-γ Concentration in Preventing SARS-CoV-2 Infection and Reinfection: A Cohort Study', Viruses, 15(3). doi: 10.3390/v15030792

Primorac D, Brlek P, Pavelić ES, Mešić J, Glavaš Weinberger D, Matišić V, i sur.. Importance of Cellular Immunity and IFN-γ Concentration in Preventing SARS-CoV-2 Infection and Reinfection: A Cohort Study. Viruses [Internet]. 20.03.2023. [pristupljeno 11.11.2024.];15(3). doi: 10.3390/v15030792

D. Primorac, et al., "Importance of Cellular Immunity and IFN-γ Concentration in Preventing SARS-CoV-2 Infection and Reinfection: A Cohort Study", Viruses, vol. 15, br. 3, Ožujak 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:782668. [Citirano: 11.11.2024.]

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Podaci o radu
Naslov (engleski)Importance of Cellular Immunity and IFN-γ Concentration in Preventing SARS-CoV-2 Infection and Reinfection: A Cohort Study
AutorDragan Primorac
AutorPetar Brlek
AutorEduard Stjepan Pavelić
AutorJana Mešić
AutorDavid Glavaš Weinberger
AutorVid Matišić
AutorVilim Molnar
AutorSaša Srića
AutorRenata Zadro
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku biologiju i genetiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Recent studies have highlighted the underestimated importance of the cellular immune response after the emergence of variants of concern (VOCs) of SARS-CoV-2, and the significantly reduced neutralizing power of antibody titers in individuals with previous SARS-CoV-2 infection or vaccination. Our study included 303 participants who were tested at St. Catherine Specialty Hospital using the Quan-T-Cell SARS-CoV-2 in combination with the Quan-T-Cell ELISA (Euroimmun Medizinische Labordiagnostika, Lübeck, Germany) for the analysis of IFN-γ concentration, and with Anti-SARS-CoV-2 QuantiVac ELISA IgG (Euroimmun Medizinische Labordiagnostika, Lübeck, Germany) for the detection of human antibodies of the immunoglobulin class IgG against the S1 domain of the SARS-CoV-2 spike protein. The statistical analysis showed a significant difference in the concentration of IFN-γ between reinfected participants and those without infection (p = 0.012). Participants who were not infected or reinfected with SARS-CoV-2 after vaccination and/or previous SARS-CoV-2 infection had a significantly higher level of cellular immunity. Furthermore, in individuals without additional vaccination, those who experienced infection/reinfection had significantly lower levels of IFN-γ compared to uninfected participants (p = 0.016). Our findings suggest a long-lasting effect of cellular immunity, measured by IFN-γ concentrations, which plays a key role in preventing infections and reinfections after the emergence of SARS-CoV-2 variants of concern.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaViruses
Brojčani podacivol. 15, br. 3, 792
e-ISSN1999-4915
DOIhttps://doi.org/10.3390/v15030792
URN:NBNurn:nbn:hr:184:782668
Datum objave publikacije2023-03-20
URL dokumentahttps://www.mdpi.com/1999-4915/15/3/792
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-08-31 07:12:18