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Scientific paper - Original scientific paper
Importance of Cellular Immunity and IFN-γ Concentration in Preventing SARS-CoV-2 Infection and Reinfection: A Cohort Study
Viruses, 15 (2023), 3; 792. https://doi.org/10.3390/v15030792
Primorac, Dragan; Brlek, Petar; Pavelić, Eduard Stjepan; Mešić, Jana; Glavaš Weinberger, David; Matišić, Vid; Molnar, Vilim; Srića, Saša; Zadro, Renata

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Primorac, D., Brlek, P., Pavelić, E. S., Mešić, J., Glavaš Weinberger, D., Matišić, V. ... Zadro, R. (2023). Importance of Cellular Immunity and IFN-γ Concentration in Preventing SARS-CoV-2 Infection and Reinfection: A Cohort Study. Viruses, 15. (3). doi: 10.3390/v15030792

Primorac, Dragan, et al. "Importance of Cellular Immunity and IFN-γ Concentration in Preventing SARS-CoV-2 Infection and Reinfection: A Cohort Study." Viruses, vol. 15, no. 3, 2023. https://doi.org/10.3390/v15030792

Primorac, Dragan, Petar Brlek, Eduard Stjepan Pavelić, Jana Mešić, David Glavaš Weinberger, Vid Matišić, Vilim Molnar, Saša Srića and Renata Zadro. "Importance of Cellular Immunity and IFN-γ Concentration in Preventing SARS-CoV-2 Infection and Reinfection: A Cohort Study." Viruses 15, no. 3 (2023). https://doi.org/10.3390/v15030792

Primorac, D., et al. (2023) 'Importance of Cellular Immunity and IFN-γ Concentration in Preventing SARS-CoV-2 Infection and Reinfection: A Cohort Study', Viruses, 15(3). doi: 10.3390/v15030792

Primorac D, Brlek P, Pavelić ES, Mešić J, Glavaš Weinberger D, Matišić V, and sur.. Importance of Cellular Immunity and IFN-γ Concentration in Preventing SARS-CoV-2 Infection and Reinfection: A Cohort Study. Viruses [Internet]. 2023 March 20 [cited 2025 January 18];15(3). doi: 10.3390/v15030792

D. Primorac, et al., "Importance of Cellular Immunity and IFN-γ Concentration in Preventing SARS-CoV-2 Infection and Reinfection: A Cohort Study", Viruses, vol. 15, no. 3, March 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:782668. [Accessed: 18 January 2025]

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Metadata
Title (english)Importance of Cellular Immunity and IFN-γ Concentration in Preventing SARS-CoV-2 Infection and Reinfection: A Cohort Study
AuthorDragan Primorac
AuthorPetar Brlek
AuthorEduard Stjepan Pavelić
AuthorJana Mešić
AuthorDavid Glavaš Weinberger
AuthorVid Matišić
AuthorVilim Molnar
AuthorSaša Srića
AuthorRenata Zadro
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Recent studies have highlighted the underestimated importance of the cellular immune response after the emergence of variants of concern (VOCs) of SARS-CoV-2, and the significantly reduced neutralizing power of antibody titers in individuals with previous SARS-CoV-2 infection or vaccination. Our study included 303 participants who were tested at St. Catherine Specialty Hospital using the Quan-T-Cell SARS-CoV-2 in combination with the Quan-T-Cell ELISA (Euroimmun Medizinische Labordiagnostika, Lübeck, Germany) for the analysis of IFN-γ concentration, and with Anti-SARS-CoV-2 QuantiVac ELISA IgG (Euroimmun Medizinische Labordiagnostika, Lübeck, Germany) for the detection of human antibodies of the immunoglobulin class IgG against the S1 domain of the SARS-CoV-2 spike protein. The statistical analysis showed a significant difference in the concentration of IFN-γ between reinfected participants and those without infection (p = 0.012). Participants who were not infected or reinfected with SARS-CoV-2 after vaccination and/or previous SARS-CoV-2 infection had a significantly higher level of cellular immunity. Furthermore, in individuals without additional vaccination, those who experienced infection/reinfection had significantly lower levels of IFN-γ compared to uninfected participants (p = 0.016). Our findings suggest a long-lasting effect of cellular immunity, measured by IFN-γ concentrations, which plays a key role in preventing infections and reinfections after the emergence of SARS-CoV-2 variants of concern.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleViruses
Numberingvol. 15, no. 3, 792
e-ISSN1999-4915
DOIhttps://doi.org/10.3390/v15030792
URN:NBNurn:nbn:hr:184:782668
Publication2023-03-20
Document URLhttps://www.mdpi.com/1999-4915/15/3/792
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-08-31 07:12:18