prikaz prve stranice dokumenta The Reliability of PCL/Anti-VEGF Electrospun Scaffolds to Support Limbal Stem Cells for Corneal Repair
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The Reliability of PCL/Anti-VEGF Electrospun Scaffolds to Support Limbal Stem Cells for Corneal Repair
Polymers, 15 (2023), 12; 2663. https://doi.org/10.3390/polym15122663
Zdraveva, Emilija; Dolenec, Tamara; Tominac Trcin, Mirna; Govorčin Bajsić, Emi; Holjevac Grgurić, Tamara; Tomljenović, Antoneta; Dekaris, Iva; Jelić, Josip; Mijovic, Budimir

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Zdraveva, E., Dolenec, T., Tominac Trcin, M., Govorčin Bajsić, E., Holjevac Grgurić, T., Tomljenović, A. ... Mijovic, B. (2023). The Reliability of PCL/Anti-VEGF Electrospun Scaffolds to Support Limbal Stem Cells for Corneal Repair. Polymers, 15. (12). doi: 10.3390/polym15122663

Zdraveva, Emilija, et al. "The Reliability of PCL/Anti-VEGF Electrospun Scaffolds to Support Limbal Stem Cells for Corneal Repair." Polymers, vol. 15, br. 12, 2023. https://doi.org/10.3390/polym15122663

Zdraveva, Emilija, Tamara Dolenec, Mirna Tominac Trcin, Emi Govorčin Bajsić, Tamara Holjevac Grgurić, Antoneta Tomljenović, Iva Dekaris, Josip Jelić i Budimir Mijovic. "The Reliability of PCL/Anti-VEGF Electrospun Scaffolds to Support Limbal Stem Cells for Corneal Repair." Polymers 15, br. 12 (2023). https://doi.org/10.3390/polym15122663

Zdraveva, E., et al. (2023) 'The Reliability of PCL/Anti-VEGF Electrospun Scaffolds to Support Limbal Stem Cells for Corneal Repair', Polymers, 15(12). doi: 10.3390/polym15122663

Zdraveva E, Dolenec T, Tominac Trcin M, Govorčin Bajsić E, Holjevac Grgurić T, Tomljenović A, i sur.. The Reliability of PCL/Anti-VEGF Electrospun Scaffolds to Support Limbal Stem Cells for Corneal Repair. Polymers [Internet]. 13.06.2023. [pristupljeno 08.05.2024.];15(12). doi: 10.3390/polym15122663

E. Zdraveva, et al., "The Reliability of PCL/Anti-VEGF Electrospun Scaffolds to Support Limbal Stem Cells for Corneal Repair", Polymers, vol. 15, br. 12, Lipanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:302114. [Citirano: 08.05.2024.]

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Naslov (engleski)The Reliability of PCL/Anti-VEGF Electrospun Scaffolds to Support Limbal Stem Cells for Corneal Repair
AutorEmilija Zdraveva
AutorTamara Dolenec
AutorMirna Tominac Trcin
AutorEmi Govorčin Bajsić
AutorTamara Holjevac Grgurić
AutorAntoneta Tomljenović
AutorIva Dekaris
AutorJosip Jelić
AutorBudimir Mijovic
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za oftalmologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Oftalmologija
Sažetak (engleski)
Since only few reported studies propose anti-vascular endothelial growth factor (anti-VEGF) delivery through electrospun scaffolds, this study greatly contributes to the potential prevention of patient’s vision loss, as it explores electrospun polycaprolactone (PCL) coated with anti-VEGF for the blockage of abnormal cornea vascularization. In terms of physicochemical properties, the biological component increased the PCL scaffold fiber diameter (by ~24%) and pore area (by ~82%), while ut slightly reduced its total porosity as the anti-VEGF solution filled the voids of the microfibrous structure. The addition of the anti-VEGF increased the scaffold stiffness almost three-fold at both strains of 5 and 10%, as well as its biodegradation rate (~36% after 60 days) with a sustained release profile after Day 4 of phosphate buffered saline incubation. In terms of scaffold application function, the PCL/Anti-VEGF scaffold proved to be more favorable for the adhesion of cultured limbal stem cells (LSCs); this was confirmed by the SEM images, where the cells showed flat and elongated conformations. Further support of the LSC growth and proliferation was confirmed by the identified p63 and CK3 markers after cell staining. These results demonstrate the advantageous effect of the surface-adsorbed anti-VEGF to stop vision loss and help damaged corneal tissue repair.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPolymers
Brojčani podacivol. 15, br. 12, 2663
e-ISSN2073-4360
DOIhttps://doi.org/10.3390/polym15122663
URN:NBNurn:nbn:hr:184:302114
Datum objave publikacije2023-06-13
URL dokumentahttps://www.mdpi.com/2073-4360/15/12/2663
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-06-19 10:49:30