prikaz prve stranice dokumenta Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo
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Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo
Nature Communications, 14 (2023), 1; 3087. https://doi.org/10.1038/s41467-023-38449-x
Sitnik, Katarzyna M.; Krstanović, Fran; Gödecke, Natascha; Rand, Ulfert; Kubsch, Tobias; Maaß, Henrike; Kim, Yeonsu; Brizić, Ilija; Čičin-Šain, Luka

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Sitnik, K. M., Krstanović, F., Gödecke, N., Rand, U., Kubsch, T., Maaß, H. ... Čičin Šain, L. (2023). Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo. Nature Communications, 14. (1). doi: 10.1038/s41467-023-38449-x

Sitnik, Katarzyna M., et al. "Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo." Nature Communications, vol. 14, br. 1, 2023. https://doi.org/10.1038/s41467-023-38449-x

Sitnik, Katarzyna M., Fran Krstanović, Natascha Gödecke, Ulfert Rand, Tobias Kubsch, Henrike Maaß, Yeonsu Kim, Ilija Brizić i Luka Čičin Šain. "Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo." Nature Communications 14, br. 1 (2023). https://doi.org/10.1038/s41467-023-38449-x

Sitnik, K. M., et al. (2023) 'Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo', Nature Communications, 14(1). doi: 10.1038/s41467-023-38449-x

Sitnik KM, Krstanović F, Gödecke N, Rand U, Kubsch T, Maaß H, i sur.. Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo. Nature Communications [Internet]. 29.05.2023. [pristupljeno 10.07.2024.];14(1). doi: 10.1038/s41467-023-38449-x

K. M. Sitnik, et al., "Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo", Nature Communications, vol. 14, br. 1, Svibanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:410870. [Citirano: 10.07.2024.]

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Naslov (engleski)Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo
AutorKatarzyna M. Sitnik
AutorFran Krstanović
AutorNatascha Gödecke
AutorUlfert Rand
AutorTobias Kubsch
AutorHenrike Maaß
AutorYeonsu Kim
AutorIlija Brizić
AutorLuka Čičin-Šain
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Abstract To date, no herpesvirus has been shown to latently persist in fibroblastic cells. Here, we show that murine cytomegalovirus, a β-herpesvirus, persists for the long term and across organs in PDGFRα-positive fibroblastic cells, with similar or higher genome loads than in the previously known sites of murine cytomegalovirus latency. Whereas murine cytomegalovirus gene transcription in PDGFRα-positive fibroblastic cells is almost completely silenced at 5 months post-infection, these cells give rise to reactivated virus ex vivo, arguing that they support latent murine cytomegalovirus infection. Notably, PDGFRα-positive fibroblastic cells also support productive virus replication during primary murine cytomegalovirus infection. Mechanistically, -deficiency promotes lytic infection but abolishes latent persistence of murine cytomegalovirus in PDGFRα-positive fibroblastic cells in vivo. In sum, fibroblastic cells have a dual role as a site of lytic murine cytomegalovirus replication and a reservoir of latent murine cytomegalovirus in vivo and STAT1 is required for murine cytomegalovirus latent persistence in vivo.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaNature Communications
Brojčani podacivol. 14, br. 1, 3087
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-023-38449-x
URN:NBNurn:nbn:hr:184:410870
Datum objave publikacije2023-05-29
ProjektŠifra: PZS-2019-02-7879
Naziv (hrvatski): Biologija citomegalovirusne infekcije u mozgu tijekom razvoja i u latenciji
Naziv (engleski): Biology of cytomegalovirus infection in developing brain and latency
Kratica: CMVbrain
Voditelj: Ilija Brizić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: PZS
URL dokumentahttps://www.nature.com/articles/s41467-023-38449-x
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-06-02 08:33:14