prikaz prve stranice dokumenta Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo
  Download
PDF 2.95 MB
Scientific paper - Original scientific paper
Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo
Nature Communications, 14 (2023), 1; 3087. https://doi.org/10.1038/s41467-023-38449-x
Sitnik, Katarzyna M.; Krstanović, Fran; Gödecke, Natascha; Rand, Ulfert; Kubsch, Tobias; Maaß, Henrike; Kim, Yeonsu; Brizić, Ilija; Čičin-Šain, Luka

Cite this document

Sitnik, K. M., Krstanović, F., Gödecke, N., Rand, U., Kubsch, T., Maaß, H. ... Čičin Šain, L. (2023). Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo. Nature Communications, 14. (1). doi: 10.1038/s41467-023-38449-x

Sitnik, Katarzyna M., et al. "Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo." Nature Communications, vol. 14, no. 1, 2023. https://doi.org/10.1038/s41467-023-38449-x

Sitnik, Katarzyna M., Fran Krstanović, Natascha Gödecke, Ulfert Rand, Tobias Kubsch, Henrike Maaß, Yeonsu Kim, Ilija Brizić and Luka Čičin Šain. "Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo." Nature Communications 14, no. 1 (2023). https://doi.org/10.1038/s41467-023-38449-x

Sitnik, K. M., et al. (2023) 'Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo', Nature Communications, 14(1). doi: 10.1038/s41467-023-38449-x

Sitnik KM, Krstanović F, Gödecke N, Rand U, Kubsch T, Maaß H, and sur.. Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo. Nature Communications [Internet]. 2023 May 29 [cited 2024 December 27];14(1). doi: 10.1038/s41467-023-38449-x

K. M. Sitnik, et al., "Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo", Nature Communications, vol. 14, no. 1, May 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:410870. [Accessed: 27 December 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo
AuthorKatarzyna M. Sitnik
AuthorFran Krstanović
AuthorNatascha Gödecke
AuthorUlfert Rand
AuthorTobias Kubsch
AuthorHenrike Maaß
AuthorYeonsu Kim
AuthorIlija Brizić
AuthorLuka Čičin-Šain
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Abstract To date, no herpesvirus has been shown to latently persist in fibroblastic cells. Here, we show that murine cytomegalovirus, a β-herpesvirus, persists for the long term and across organs in PDGFRα-positive fibroblastic cells, with similar or higher genome loads than in the previously known sites of murine cytomegalovirus latency. Whereas murine cytomegalovirus gene transcription in PDGFRα-positive fibroblastic cells is almost completely silenced at 5 months post-infection, these cells give rise to reactivated virus ex vivo, arguing that they support latent murine cytomegalovirus infection. Notably, PDGFRα-positive fibroblastic cells also support productive virus replication during primary murine cytomegalovirus infection. Mechanistically, -deficiency promotes lytic infection but abolishes latent persistence of murine cytomegalovirus in PDGFRα-positive fibroblastic cells in vivo. In sum, fibroblastic cells have a dual role as a site of lytic murine cytomegalovirus replication and a reservoir of latent murine cytomegalovirus in vivo and STAT1 is required for murine cytomegalovirus latent persistence in vivo.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleNature Communications
Numberingvol. 14, no. 1, 3087
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-023-38449-x
URN:NBNurn:nbn:hr:184:410870
Publication2023-05-29
ProjectNumber: PZS-2019-02-7879
Title (croatian): Biologija citomegalovirusne infekcije u mozgu tijekom razvoja i u latenciji
Title (english): Biology of cytomegalovirus infection in developing brain and latency
Acronym: CMVbrain
Leader: Ilija Brizić
Jurisdiction: Croatia
Funding stream: PZS
Document URLhttps://www.nature.com/articles/s41467-023-38449-x
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-06-02 08:33:14