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Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas
Collegium antropologicum, 35 - supplement 2 (2011), 2; 7-10. urn:nbn:hr:184:867704
Fučkar Čupić, Dora; Cini Tešar, Eleonora; Matušan Ilijaš, Koviljka; Nemrava, Johan; Kovačević, Marinko; Mustać, Elvira

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Fučkar Čupić, D., Cini Tešar, E., Matušan Ilijaš, K., Nemrava, J., Kovačević, M. i Mustać, E. (2011). Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas. Collegium antropologicum, 35 - supplement 2. (2), 7-10. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:867704

Fučkar Čupić, Dora, et al. "Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas." Collegium antropologicum, vol. 35 - supplement 2, br. 2, 2011, str. 7-10. https://urn.nsk.hr/urn:nbn:hr:184:867704

Fučkar Čupić, Dora, Eleonora Cini Tešar, Koviljka Matušan Ilijaš, Johan Nemrava, Marinko Kovačević i Elvira Mustać. "Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas." Collegium antropologicum 35 - supplement 2, br. 2 (2011): 7-10. https://urn.nsk.hr/urn:nbn:hr:184:867704

Fučkar Čupić, D., et al. (2011) 'Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas', Collegium antropologicum, 35 - supplement 2(2), str. 7-10. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:867704 (Datum pristupa: 06.05.2024.)

Fučkar Čupić D, Cini Tešar E, Matušan Ilijaš K, Nemrava J, Kovačević M, Mustać E. Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas. Collegium antropologicum [Internet]. 2011. [pristupljeno 06.05.2024.];35 - supplement 2(2):7-10. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:867704

D. Fučkar Čupić, E. Cini Tešar, K. Matušan Ilijaš, J. Nemrava, M. Kovačević i E. Mustać, "Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas", Collegium antropologicum, vol. 35 - supplement 2, br. 2, str. 7-10, 2011. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:867704. [Citirano: 06.05.2024.]

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Naslov (engleski)Expression of Matrix Metalloproteinase 9 in Primary and Recurrent Breast Carcinomas
AutorDora Fučkar Čupić
AutorEleonora Cini Tešar
AutorKoviljka Matušan Ilijaš
AutorJohan Nemrava
AutorMarinko Kovačević
AutorElvira Mustać
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za urologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Urologija
Sažetak (engleski)
The matrix metalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases that are secreted as inactive precursors, which are activated by cleavage of an N-terminal pro-peptide. Their basic mechanisms of action include cancer cell growth, differentiation, apoptosis, migration and invasion, and the regulation of tumour angiogenesis and immune surveillance. The expression of MMP2 and MMP9 has been associated with high potential of metastasis in several human carcinomas including breast cancer. The 29 female patients, 9 premenopausal and 20 postmenopausal, aged from 37 to 79 years were included in this study. Tissue samples were examined in 29 primary and 48 recurrent carcinomas using the tissue microarrays which included 102 cores of primary breast carcinomas and 96 of recurrent breast carcinomas. Immunohistochemistry determined a pattern of expression for MMP9. The staining was diffuse cytoplasmic, strong, moderate, faint/weak and negative. The majority of the breast carcinomas stained homogenously for MMP9 on tumor cells. Statistically significant correlation was found for the expression of MMP9 between primary and recurrent breast carcinomas in general (p<0.001) and in tumors that were grouped as recurrence before (p=0.039) and after 24 months (p<0.001). Strong expression of MMP9 was observed in primary tumors that recurred after 24 months, median: 162.5 (score range 0–300) and those tumors that recurred before 24 months of the initial diagnosis, median: 102.5 (score range 0–250) (p=0.026).
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaCollegium antropologicum
Brojčani podacivol. 35 - supplement 2, br. 2, str. 7-10
p-ISSN0350-6134
e-ISSN1848-9486
URN:NBNurn:nbn:hr:184:867704
Datum objave publikacije2011
URL dokumentahttps://hrcak.srce.hr/72215
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-05-17 12:16:34