prikaz prve stranice dokumenta Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event
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Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event
Scandinavian Journal of Immunology, 75 (2012), 2; 231-242. https://doi.org/10.1111/j.1365-3083.2011.02646.x
Peršić, Viktor; Ružić, Alen; Miletić, Bojan; Samsa Travica, Dijana; Rakić, Marijana; Raljević, Damir; Pejčinović Pehar, Vesna; Eminović, Senija; Zaputović, Luka; Laškarin, Gordana

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Peršić, V., Ružić, A., Miletić, B., Samsa Travica, D., Rakić, M., Raljević, D. ... Laškarin, G. (2012). Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event. Scandinavian Journal of Immunology, 75. (2), 231-242. doi: 10.1111/j.1365-3083.2011.02646.x

Peršić, Viktor, et al. "Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event." Scandinavian Journal of Immunology, vol. 75, br. 2, 2012, str. 231-242. https://doi.org/10.1111/j.1365-3083.2011.02646.x

Peršić, Viktor, Alen Ružić, Bojan Miletić, Dijana Samsa Travica, Marijana Rakić, Damir Raljević, Vesna Pejčinović Pehar, Senija Eminović, Luka Zaputović i Gordana Laškarin. "Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event." Scandinavian Journal of Immunology 75, br. 2 (2012): 231-242. https://doi.org/10.1111/j.1365-3083.2011.02646.x

Peršić, V., et al. (2012) 'Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event', Scandinavian Journal of Immunology, 75(2), str. 231-242. doi: 10.1111/j.1365-3083.2011.02646.x

Peršić V, Ružić A, Miletić B, Samsa Travica D, Rakić M, Raljević D, i sur.. Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event. Scandinavian Journal of Immunology [Internet]. 2012. [pristupljeno 14.11.2024.];75(2):231-242. doi: 10.1111/j.1365-3083.2011.02646.x

V. Peršić, et al., "Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event", Scandinavian Journal of Immunology, vol. 75, br. 2, str. 231-242, 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:939368. [Citirano: 14.11.2024.]

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Naslov (engleski)Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event
AutorViktor Peršić
AutorAlen Ružić
AutorBojan Miletić
AutorDijana Samsa Travica
AutorMarijana Rakić
AutorDamir Raljević
AutorVesna Pejčinović Pehar
AutorSenija Eminović
AutorLuka Zaputović
AutorGordana Laškarin
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za rehabilitacijsku i sportsku medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Sažetak (engleski)
We aimed to analyse granulysin (GNLY)-mediated cytotoxicity in the peripheral blood of patients with non-ST-segment elevation myocardial infarction (NSTEMI) treated with anti-ischaemic drug therapy. Thirty-nine NSTEMI patients with a median age of 70 years and 28 age-matched healthy subjects were enrolled in this study. On day 7 after MI, the number of GNLY+ lymphocytes in the peripheral blood increased approximately six-fold of that in the healthy subjects, measured by flow cytometry. On day 14, the number of GNLY+ cells significantly decreased in T, NKT, and both CD56+dim and CD56+bright NK subsets. GNLY+ CD3+ and GNLY+ CD56+ cells infiltrated central zone of myocardial infarction (MI). In persons who died in the first week after MI, GNLY+ cells were found within accumulation of apoptotic leucocytes and reached the apoptotic cardiomyocytes in border MI zones probably due to the influence of interleukin-15 in peri- necrotic cardiomyocytes, as it is was shown by immunohistology. By day 28, the percentage of GNLY+ lymphocytes in peripheral blood returned to the levels similar to that of the healthy subjects. Anti-GNLY mAb decreased apoptosis of K562 targets using peripheral blood NK cells from days 7 and 28 after MI, while in assays using cells from days 1 and 21, both anti-GNLY and anti-perforin mAbs were required to significantly decrease apoptosis. Using NK cells from day 14, K562 apoptosis was nearly absent. In conclusion, it seems that GNLY+ lymphocytes, probably attracted by IL-15, not only participate partially in myocardial cell apoptosis, but also hasten resolution of cardiac leucocyte infiltration in patients with NSTEMI.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaScandinavian Journal of Immunology
Brojčani podacivol. 75, br. 2, str. 231-242
p-ISSN0300-9475
DOIhttps://doi.org/10.1111/j.1365-3083.2011.02646.x
URN:NBNurn:nbn:hr:184:939368
Datum objave publikacije2012
URL dokumentahttp://bib.irb.hr/1058642
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-04-11 09:52:18