prikaz prve stranice dokumenta Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event
  Download
PDF 1.05 MB
Scientific paper - Original scientific paper
Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event
Scandinavian Journal of Immunology, 75 (2012), 2; 231-242. https://doi.org/10.1111/j.1365-3083.2011.02646.x
Peršić, Viktor; Ružić, Alen; Miletić, Bojan; Samsa Travica, Dijana; Rakić, Marijana; Raljević, Damir; Pejčinović Pehar, Vesna; Eminović, Senija; Zaputović, Luka; Laškarin, Gordana

Cite this document

Peršić, V., Ružić, A., Miletić, B., Samsa Travica, D., Rakić, M., Raljević, D. ... Laškarin, G. (2012). Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event. Scandinavian Journal of Immunology, 75. (2), 231-242. doi: 10.1111/j.1365-3083.2011.02646.x

Peršić, Viktor, et al. "Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event." Scandinavian Journal of Immunology, vol. 75, no. 2, 2012, pp. 231-242. https://doi.org/10.1111/j.1365-3083.2011.02646.x

Peršić, Viktor, Alen Ružić, Bojan Miletić, Dijana Samsa Travica, Marijana Rakić, Damir Raljević, Vesna Pejčinović Pehar, Senija Eminović, Luka Zaputović and Gordana Laškarin. "Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event." Scandinavian Journal of Immunology 75, no. 2 (2012): 231-242. https://doi.org/10.1111/j.1365-3083.2011.02646.x

Peršić, V., et al. (2012) 'Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event', Scandinavian Journal of Immunology, 75(2), pp. 231-242. doi: 10.1111/j.1365-3083.2011.02646.x

Peršić V, Ružić A, Miletić B, Samsa Travica D, Rakić M, Raljević D, and sur.. Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event. Scandinavian Journal of Immunology [Internet]. 2012 [cited 2024 December 25];75(2):231-242. doi: 10.1111/j.1365-3083.2011.02646.x

V. Peršić, et al., "Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event", Scandinavian Journal of Immunology, vol. 75, no. 2, pp. 231-242, 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:939368. [Accessed: 25 December 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium after an Acute Coronary Event
AuthorViktor Peršić
AuthorAlen Ružić
AuthorBojan Miletić
AuthorDijana Samsa Travica
AuthorMarijana Rakić
AuthorDamir Raljević
AuthorVesna Pejčinović Pehar
AuthorSenija Eminović
AuthorLuka Zaputović
AuthorGordana Laškarin
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Rehabilitatiom Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
We aimed to analyse granulysin (GNLY)-mediated cytotoxicity in the peripheral blood of patients with non-ST-segment elevation myocardial infarction (NSTEMI) treated with anti-ischaemic drug therapy. Thirty-nine NSTEMI patients with a median age of 70 years and 28 age-matched healthy subjects were enrolled in this study. On day 7 after MI, the number of GNLY+ lymphocytes in the peripheral blood increased approximately six-fold of that in the healthy subjects, measured by flow cytometry. On day 14, the number of GNLY+ cells significantly decreased in T, NKT, and both CD56+dim and CD56+bright NK subsets. GNLY+ CD3+ and GNLY+ CD56+ cells infiltrated central zone of myocardial infarction (MI). In persons who died in the first week after MI, GNLY+ cells were found within accumulation of apoptotic leucocytes and reached the apoptotic cardiomyocytes in border MI zones probably due to the influence of interleukin-15 in peri- necrotic cardiomyocytes, as it is was shown by immunohistology. By day 28, the percentage of GNLY+ lymphocytes in peripheral blood returned to the levels similar to that of the healthy subjects. Anti-GNLY mAb decreased apoptosis of K562 targets using peripheral blood NK cells from days 7 and 28 after MI, while in assays using cells from days 1 and 21, both anti-GNLY and anti-perforin mAbs were required to significantly decrease apoptosis. Using NK cells from day 14, K562 apoptosis was nearly absent. In conclusion, it seems that GNLY+ lymphocytes, probably attracted by IL-15, not only participate partially in myocardial cell apoptosis, but also hasten resolution of cardiac leucocyte infiltration in patients with NSTEMI.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleScandinavian Journal of Immunology
Numberingvol. 75, no. 2, pp. 231-242
p-ISSN0300-9475
DOIhttps://doi.org/10.1111/j.1365-3083.2011.02646.x
URN:NBNurn:nbn:hr:184:939368
Publication2012
Document URLhttp://bib.irb.hr/1058642
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-04-11 09:52:18