prikaz prve stranice dokumenta Analysis of granulysin-mediated cytotoxicity in peripheral blood of patients with psoriatic arthritis
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Analysis of granulysin-mediated cytotoxicity in peripheral blood of patients with psoriatic arthritis
Rheumatology international, 32 (2012), 9; 2777-2784. https://doi.org/10.1007/s00296-011-2013-9
Massari, Dražen; Prpić-Massari, Larisa; Kehler, Tatjana; Kaštelan, Marija; Ćurkovic, Božidar; Peršić, Viktor; Ružić, Alen; Laškarin, Gordana

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Massari, D., Prpić Massari, L., Kehler, T., Kaštelan, M., Ćurkovic, B., Peršić, V. ... Laškarin, G. (2012). Analysis of granulysin-mediated cytotoxicity in peripheral blood of patients with psoriatic arthritis. Rheumatology international, 32. (9), 2777-2784. doi: 10.1007/s00296-011-2013-9

Massari, Dražen, et al. "Analysis of granulysin-mediated cytotoxicity in peripheral blood of patients with psoriatic arthritis." Rheumatology international, vol. 32, br. 9, 2012, str. 2777-2784. https://doi.org/10.1007/s00296-011-2013-9

Massari, Dražen, Larisa Prpić Massari, Tatjana Kehler, Marija Kaštelan, Božidar Ćurkovic, Viktor Peršić, Alen Ružić i Gordana Laškarin. "Analysis of granulysin-mediated cytotoxicity in peripheral blood of patients with psoriatic arthritis." Rheumatology international 32, br. 9 (2012): 2777-2784. https://doi.org/10.1007/s00296-011-2013-9

Massari, D., et al. (2012) 'Analysis of granulysin-mediated cytotoxicity in peripheral blood of patients with psoriatic arthritis', Rheumatology international, 32(9), str. 2777-2784. doi: 10.1007/s00296-011-2013-9

Massari D, Prpić Massari L, Kehler T, Kaštelan M, Ćurkovic B, Peršić V, i sur.. Analysis of granulysin-mediated cytotoxicity in peripheral blood of patients with psoriatic arthritis. Rheumatology international [Internet]. 2012. [pristupljeno 16.04.2024.];32(9):2777-2784. doi: 10.1007/s00296-011-2013-9

D. Massari, et al., "Analysis of granulysin-mediated cytotoxicity in peripheral blood of patients with psoriatic arthritis", Rheumatology international, vol. 32, br. 9, str. 2777-2784, 2012. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:367270. [Citirano: 16.04.2024.]

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Podaci o radu
Naslov (engleski)Analysis of granulysin-mediated cytotoxicity in peripheral blood of patients with psoriatic arthritis
AutorDražen Massari
AutorLarisa Prpić-Massari
AutorTatjana Kehler
AutorMarija Kaštelan
AutorBožidar Ćurkovic
AutorViktor Peršić
AutorAlen Ružić
AutorGordana Laškarin
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za dermatovenerologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za internu medicinu)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za rehabilitacijsku i sportsku medicinu)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Imunologija
Sažetak (engleski)
The objective of the present study was to investigate possible changes in granulysin (GNLY)-mediated cytotoxicity of peripheral blood lymphocytes in psoriatic arthritis (PsA) patients with respect to different phases of the disease. We prospectively enrolled 25 PsA patients in the active phase, 26 PsA patients in remission and 24 healthy controls. The simultaneous detection of intracellular GNLY and cell surface antigens (CD3 and CD56) was performed with flow cytometry. GNLY apoptotic protein was visualised by immunocytochemistry. Natural killer (NK) cell cytotoxicity was analysed with a cytotoxicity assay against human erythroleukaemia K-562 cells. The percentage of GNLY(+) cells did not differ significantly between PsA patients in the acute phase and those in remission ; however, it was always higher than in healthy examinees due to the increased percentage of GNLY(+) cells within T cells, NKT cells, and both, and in the CD56(+dim) and CD56(+bright) NK subsets. The mean fluorescence intensity for GNLY was higher in all lymphocyte subpopulations in the acute phase than in remission and in healthy controls. Accordingly, GNLY-mediated NK cell cytotoxicity against K-562 cells of active phase PsA patients was significantly higher than that in patients in remission or in healthy controls. These findings demonstrated the involvement of GNLY in the worsening of PsA and suggested that GNLY mediated the development of joint lesions.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaRheumatology international
Brojčani podacivol. 32, br. 9, str. 2777-2784
p-ISSN0172-8172
DOIhttps://doi.org/10.1007/s00296-011-2013-9
URN:NBNurn:nbn:hr:184:367270
Datum objave publikacije2012
URL dokumentahttp://bib.irb.hr/534002
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-04-11 09:34:12