prikaz prve stranice dokumenta At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success
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At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success
International Journal of Molecular Sciences, 23 (2022), 9; 4926. https://doi.org/10.3390/ijms23094926
Lombardelli, Letizia; Logiodice, Federica; Kullolli, Ornela; Haller, Herman; Agostinis, Chiara; Bulla, Roberta; Rukavina, Daniel; Piccinni, Marie-Pierre

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Lombardelli, L., Logiodice, F., Kullolli, O., Haller, H., Agostinis, C., Bulla, R. ... Piccinni, M. P. (2022). At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success. International Journal of Molecular Sciences, 23. (9). doi: 10.3390/ijms23094926

Lombardelli, Letizia, et al. "At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success." International Journal of Molecular Sciences, vol. 23, br. 9, 2022. https://doi.org/10.3390/ijms23094926

Lombardelli, Letizia, Federica Logiodice, Ornela Kullolli, Herman Haller, Chiara Agostinis, Roberta Bulla, Daniel Rukavina i Marie Pierre Piccinni. "At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success." International Journal of Molecular Sciences 23, br. 9 (2022). https://doi.org/10.3390/ijms23094926

Lombardelli, L., et al. (2022) 'At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success', International Journal of Molecular Sciences, 23(9). doi: 10.3390/ijms23094926

Lombardelli L, Logiodice F, Kullolli O, Haller H, Agostinis C, Bulla R, i sur.. At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success. International Journal of Molecular Sciences [Internet]. 28.04.2022. [pristupljeno 05.05.2024.];23(9). doi: 10.3390/ijms23094926

L. Lombardelli, et al., "At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success", International Journal of Molecular Sciences, vol. 23, br. 9, Travanj 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:422761. [Citirano: 05.05.2024.]

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Naslov (engleski)At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success
AutorLetizia Lombardelli
AutorFederica Logiodice
AutorOrnela Kullolli
AutorHerman Haller
AutorChiara Agostinis
AutorRoberta Bulla
AutorDaniel Rukavina
AutorMarie-Pierre Piccinni
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za ginekologiju i opstetriciju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
We investigated the role of rhIL-35, at low concentrations compatible with those produced by human trophoblast cells (less than 1 ng/mL), on human T helper (Th) cell functions and the presence of decidual IL-35-producing Th cells in human pregnancy. We found that human trophoblast cells produced IL-35 but not IL-4 or IL-10. RhIL-35, at concentrations produced by human trophoblasts, polarized T cells towards IL-35+, IL-10+, IL-4+ Th2-type cells and to Foxp3+ EBI3+ p35+ T reg cells producing IL-35 but not IL-10 and IL-4. Moreover, rhIL-35 at low concentrations did not suppress the proliferation of Th cells but stimulated IL-4 and IL-10 production by established Th clones. In particular, Th1-type clones acquired the capacity to produce IL-4. In addition, purified human trophoblast cell supernatants containing IL-35 upregulated IL-4 and IL-10 production by Th clones. Finally, IL-35+, IL-10+, IL-4+ Th2-type cells, which were found to be induced by low concentrations of IL-35 compatible with those produced by human trophoblasts, are exclusively present in the decidua of a successful pregnancy and at the embryo implantation site, suggesting their stringent dependence on trophoblast cells. Thus, the proximity of Th cells to IL-35-producing trophoblasts could be the determining factor for the differentiation of IL-35+, IL-10+, IL-4+ Th2-type cells that are crucial for human pregnancy success.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational Journal of Molecular Sciences
Brojčani podacivol. 23, br. 9, 4926
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms23094926
URN:NBNurn:nbn:hr:184:422761
Datum objave publikacije2022-04-28
URL dokumentahttps://www.mdpi.com/1422-0067/23/9/4926
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-02-02 17:26:54