prikaz prve stranice dokumenta At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success
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Scientific paper - Original scientific paper
At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success
International Journal of Molecular Sciences, 23 (2022), 9; 4926. https://doi.org/10.3390/ijms23094926
Lombardelli, Letizia; Logiodice, Federica; Kullolli, Ornela; Haller, Herman; Agostinis, Chiara; Bulla, Roberta; Rukavina, Daniel; Piccinni, Marie-Pierre

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Lombardelli, L., Logiodice, F., Kullolli, O., Haller, H., Agostinis, C., Bulla, R. ... Piccinni, M. P. (2022). At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success. International Journal of Molecular Sciences, 23. (9). doi: 10.3390/ijms23094926

Lombardelli, Letizia, et al. "At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success." International Journal of Molecular Sciences, vol. 23, no. 9, 2022. https://doi.org/10.3390/ijms23094926

Lombardelli, Letizia, Federica Logiodice, Ornela Kullolli, Herman Haller, Chiara Agostinis, Roberta Bulla, Daniel Rukavina and Marie Pierre Piccinni. "At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success." International Journal of Molecular Sciences 23, no. 9 (2022). https://doi.org/10.3390/ijms23094926

Lombardelli, L., et al. (2022) 'At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success', International Journal of Molecular Sciences, 23(9). doi: 10.3390/ijms23094926

Lombardelli L, Logiodice F, Kullolli O, Haller H, Agostinis C, Bulla R, and sur.. At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success. International Journal of Molecular Sciences [Internet]. 2022 April 28 [cited 2024 May 15];23(9). doi: 10.3390/ijms23094926

L. Lombardelli, et al., "At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success", International Journal of Molecular Sciences, vol. 23, no. 9, April 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:422761. [Accessed: 15 May 2024]

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Title (english)At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success
AuthorLetizia Lombardelli
AuthorFederica Logiodice
AuthorOrnela Kullolli
AuthorHerman Haller
AuthorChiara Agostinis
AuthorRoberta Bulla
AuthorDaniel Rukavina
AuthorMarie-Pierre Piccinni
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Gynaecology and Obstetrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
We investigated the role of rhIL-35, at low concentrations compatible with those produced by human trophoblast cells (less than 1 ng/mL), on human T helper (Th) cell functions and the presence of decidual IL-35-producing Th cells in human pregnancy. We found that human trophoblast cells produced IL-35 but not IL-4 or IL-10. RhIL-35, at concentrations produced by human trophoblasts, polarized T cells towards IL-35+, IL-10+, IL-4+ Th2-type cells and to Foxp3+ EBI3+ p35+ T reg cells producing IL-35 but not IL-10 and IL-4. Moreover, rhIL-35 at low concentrations did not suppress the proliferation of Th cells but stimulated IL-4 and IL-10 production by established Th clones. In particular, Th1-type clones acquired the capacity to produce IL-4. In addition, purified human trophoblast cell supernatants containing IL-35 upregulated IL-4 and IL-10 production by Th clones. Finally, IL-35+, IL-10+, IL-4+ Th2-type cells, which were found to be induced by low concentrations of IL-35 compatible with those produced by human trophoblasts, are exclusively present in the decidua of a successful pregnancy and at the embryo implantation site, suggesting their stringent dependence on trophoblast cells. Thus, the proximity of Th cells to IL-35-producing trophoblasts could be the determining factor for the differentiation of IL-35+, IL-10+, IL-4+ Th2-type cells that are crucial for human pregnancy success.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational Journal of Molecular Sciences
Numberingvol. 23, no. 9, 4926
e-ISSN1422-0067
DOIhttps://doi.org/10.3390/ijms23094926
URN:NBNurn:nbn:hr:184:422761
Publication2022-04-28
Document URLhttps://www.mdpi.com/1422-0067/23/9/4926
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-02-02 17:26:54