Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver

Benić, Ante; Mikašinović, Sanja; Wensveen, Felix M.; Polić, Bojan

doi:10.3390/metabo13020153

prikaz prve stranice dokumenta Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver

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Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver

Metabolites, 13 (2023), 2; 153. https://doi.org/10.3390/metabo13020153

Benić, Ante; Mikašinović, Sanja; Wensveen, Felix M.; Polić, Bojan

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APA 6th Edition

Benić, A., Mikašinović, S., Wensveen, F. M. i Polić, B. (2023). Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver. Metabolites, 13. (2). doi: 10.3390/metabo13020153

MLA 8th Edition

Benić, Ante, et al. "Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver." Metabolites, vol. 13, br. 2, 2023. https://doi.org/10.3390/metabo13020153

Chicago 17th Edition

Benić, Ante, Sanja Mikašinović, Felix M. Wensveen i Bojan Polić. "Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver." Metabolites 13, br. 2 (2023). https://doi.org/10.3390/metabo13020153

Harvard

Benić, A., et al. (2023) 'Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver', Metabolites, 13(2). doi: 10.3390/metabo13020153

Vancouver

Benić A, Mikašinović S, Wensveen FM, Polić B. Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver. Metabolites [Internet]. 19.01.2023. [pristupljeno 30.12.2024.];13(2). doi: 10.3390/metabo13020153

IEEE

A. Benić, S. Mikašinović, F. M. Wensveen i B. Polić, "Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver", Metabolites, vol. 13, br. 2, Siječanj 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:452625. [Citirano: 30.12.2024.]

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Naslov (engleski)	Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver
Autor	Ante Benić
Autor	Sanja Mikašinović
Autor	Felix M. Wensveen
Autor	Bojan Polić
Autorova ustanova	Sveučilište u Rijeci Medicinski fakultet (Katedra za histologiju i embriologiju)
Znanstveno / umjetničko područje, polje i grana	BIOMEDICINA I ZDRAVSTVO Temeljne medicinske znanosti
Sažetak (engleski)	In their aspiration to become healthy, people are known to follow extreme diets. However, the acute impact on organs regulating systemic metabolism is not well characterized. Here, we investigated the acute impact of six extreme diets on the liver in mice. Most diets did not lead to clear pathology after short-term feeding. However, two weeks of feeding with a high protein diet (HPD) resulted in an acute increase of liver enzymes in the blood, indicative of liver damage. Histology revealed the formation of necrotic lesions in this organ which persisted for several weeks. Flow cytometric analysis of hepatic immune cell populations showed that HPD feeding induced activation of macrophages and neutrophils. Neutralization of the pro-inflammatory cytokine IL-1β or depletion of macrophages with clodronate-loaded liposomes or with genetic models did not ameliorate liver necrosis. In contrast, the depletion of neutrophils prevented HPD-induced hepatic inflammation. After prolonged feeding, HPD-feeding was associated with a strong increase of the cytokines IL-10 and IL-27, suggesting that anti-inflammatory mediators are activated to prevent nutrient-overload-induced damage to the liver. In summary, whereas our data indicates that most extreme diets do not have a major impact on the liver within two weeks, diets with a very high protein content may lead to severe, acute hepatic damage and should therefore be avoided.
Ključne riječi (engleski)
Jezik	engleski
Vrsta publikacije	Znanstveni rad - Izvorni znanstveni rad
Status objave	Objavljen
Vrsta recenzije	Recenziran - međunarodna recenzija
Verzija publikacije	Objavljena verzija rada (izdavačev PDF)
Naslov časopisa	Metabolites
Brojčani podaci	vol. 13, br. 2, 153
e-ISSN	2218-1989
DOI	https://doi.org/10.3390/metabo13020153
URN:NBN	urn:nbn:hr:184:452625
Datum objave publikacije	2023-01-19
Projekt	Šifra: IP-2016-06-9306 Naziv (hrvatski): Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini Naziv (engleski): Immune mechanisms in development of inflammation and metabolic syndrome in obesity Kratica: INFLAMETAB Voditelj: Bojan Polić Pravna nadležnost: Hrvatska Financijer: HRZZ Linija financiranja: IP
Projekt	Šifra: IP-2016-06-8027 Naziv (hrvatski): Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva Naziv (engleski): Rewriting memory; Manipulation of T cell memory to enhance vaccine efficiency Kratica: T-MEMORY Voditelj: Felix Martinus Wensveen Pravna nadležnost: Hrvatska Financijer: HRZZ Linija financiranja: IP
Projekt	Šifra: IP-CORONA-2020-04-2045 Naziv (hrvatski): Manipuliranje imunološkom memorijom: razvoj novih strategija u svrhu stvaranja boljeg memorijskog CD8 T-staničnog odgovora protiv COVID-19 nakon cijepljenja Naziv (engleski): Memory Manipulation: Development of novel strategies to enhance the memory CD8 T-cell response against COVID-19 following vaccination Kratica: CORONAWAI Voditelj: Felix Martinus Wensveen Pravna nadležnost: Hrvatska Financijer: HRZZ Linija financiranja: IP-CORONA
URL dokumenta	https://www.mdpi.com/2218-1989/13/2/153
Vrsta resursa	Tekst
Prava pristupa	Otvoreni pristup
Uvjeti korištenja
Datum i vrijeme pohrane	2023-01-25 14:07:38