prikaz prve stranice dokumenta Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver
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Scientific paper - Original scientific paper
Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver
Metabolites, 13 (2023), 2; 153. https://doi.org/10.3390/metabo13020153
Benić, Ante; Mikašinović, Sanja; Wensveen, Felix M.; Polić, Bojan

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Benić, A., Mikašinović, S., Wensveen, F. M. & Polić, B. (2023). Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver. Metabolites, 13. (2). doi: 10.3390/metabo13020153

Benić, Ante, et al. "Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver." Metabolites, vol. 13, no. 2, 2023. https://doi.org/10.3390/metabo13020153

Benić, Ante, Sanja Mikašinović, Felix M. Wensveen and Bojan Polić. "Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver." Metabolites 13, no. 2 (2023). https://doi.org/10.3390/metabo13020153

Benić, A., et al. (2023) 'Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver', Metabolites, 13(2). doi: 10.3390/metabo13020153

Benić A, Mikašinović S, Wensveen FM, Polić B. Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver. Metabolites [Internet]. 2023 January 19 [cited 2024 November 19];13(2). doi: 10.3390/metabo13020153

A. Benić, S. Mikašinović, F. M. Wensveen and B. Polić, "Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver", Metabolites, vol. 13, no. 2, January 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:452625. [Accessed: 19 November 2024]

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Metadata
Title (english)Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver
AuthorAnte Benić
AuthorSanja Mikašinović
AuthorFelix M. Wensveen
AuthorBojan Polić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
In their aspiration to become healthy, people are known to follow extreme diets. However, the acute impact on organs regulating systemic metabolism is not well characterized. Here, we investigated the acute impact of six extreme diets on the liver in mice. Most diets did not lead to clear pathology after short-term feeding. However, two weeks of feeding with a high protein diet (HPD) resulted in an acute increase of liver enzymes in the blood, indicative of liver damage. Histology revealed the formation of necrotic lesions in this organ which persisted for several weeks. Flow cytometric analysis of hepatic immune cell populations showed that HPD feeding induced activation of macrophages and neutrophils. Neutralization of the pro-inflammatory cytokine IL-1β or depletion of macrophages with clodronate-loaded liposomes or with genetic models did not ameliorate liver necrosis. In contrast, the depletion of neutrophils prevented HPD-induced hepatic inflammation. After prolonged feeding, HPD-feeding was associated with a strong increase of the cytokines IL-10 and IL-27, suggesting that anti-inflammatory mediators are activated to prevent nutrient-overload-induced damage to the liver. In summary, whereas our data indicates that most extreme diets do not have a major impact on the liver within two weeks, diets with a very high protein content may lead to severe, acute hepatic damage and should therefore be avoided.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMetabolites
Numberingvol. 13, no. 2, 153
e-ISSN2218-1989
DOIhttps://doi.org/10.3390/metabo13020153
URN:NBNurn:nbn:hr:184:452625
Publication2023-01-19
ProjectNumber: IP-2016-06-9306
Title (croatian): Imunosni mehanizmi u razvoju upale i metaboličkog sindroma u debljini
Title (english): Immune mechanisms in development of inflammation and metabolic syndrome in obesity
Acronym: INFLAMETAB
Leader: Bojan Polić
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: IP-2016-06-8027
Title (croatian): Preuređivanje memorije: Manipuliranje T-staničnom memorijom u svrhu unapređenja učinkovitosti cjepiva
Title (english): Rewriting memory; Manipulation of T cell memory to enhance vaccine efficiency
Acronym: T-MEMORY
Leader: Felix Martinus Wensveen
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: IP-CORONA-2020-04-2045
Title (croatian): Manipuliranje imunološkom memorijom: razvoj novih strategija u svrhu stvaranja boljeg memorijskog CD8 T-staničnog odgovora protiv COVID-19 nakon cijepljenja
Title (english): Memory Manipulation: Development of novel strategies to enhance the memory CD8 T-cell response against COVID-19 following vaccination
Acronym: CORONAWAI
Leader: Felix Martinus Wensveen
Jurisdiction: Croatia
Funding stream: IP-CORONA
Document URLhttps://www.mdpi.com/2218-1989/13/2/153
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-01-25 14:07:38