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On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc
International archives of allergy and immunology, 119 (1999), 1; 13-22. https://doi.org/10.1159/000024170
Ravlić Gulan, Jagoda; Radošević-Stašić, Biserka; Trobonjača, Zlatko; Petković, Marija; Ćuk, Mira; Rukavina, Daniel

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Ravlić Gulan, J., Radošević Stašić, B., Trobonjača, Z., Petković, M., Ćuk, M. i Rukavina, D. (1999). On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc. International archives of allergy and immunology, 119. (1), 13-22. doi: 10.1159/000024170

Ravlić Gulan, Jagoda, et al. "On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc." International archives of allergy and immunology, vol. 119, br. 1, 1999, str. 13-22. https://doi.org/10.1159/000024170

Ravlić Gulan, Jagoda, Biserka Radošević Stašić, Zlatko Trobonjača, Marija Petković, Mira Ćuk i Daniel Rukavina. "On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc." International archives of allergy and immunology 119, br. 1 (1999): 13-22. https://doi.org/10.1159/000024170

Ravlić Gulan, J., et al. (1999) 'On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc', International archives of allergy and immunology, 119(1), str. 13-22. doi: 10.1159/000024170

Ravlić Gulan J, Radošević Stašić B, Trobonjača Z, Petković M, Ćuk M, Rukavina D. On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc. International archives of allergy and immunology [Internet]. 1999. [pristupljeno 02.12.2024.];119(1):13-22. doi: 10.1159/000024170

J. Ravlić Gulan, B. Radošević Stašić, Z. Trobonjača, M. Petković, M. Ćuk i D. Rukavina, "On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc", International archives of allergy and immunology, vol. 119, br. 1, str. 13-22, 1999. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:533296. [Citirano: 02.12.2024.]

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Naslov (engleski)On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc
AutorJagoda Ravlić Gulan
AutorBiserka Radošević-Stašić
AutorZlatko Trobonjača
AutorMarija Petković
AutorMira Ćuk
AutorDaniel Rukavina
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
Effects of peptidoglycan linked with zinc (PGM-Zn) were investigated on PFC-generation to SRBC and SRBC-unrelated antibody production in primary and secondary immune response in mice depleted in vivo of CD4+ and/or CD8+ T lymphocytes. PGM-Zn in non-depleted mice stimulated the PFC generation and IgM or IgG and IgG1 production in primary and secondary reaction. Single depletion of CD4 or CD8+ T cells did not change this ability. The effects of PGM-Zn after CD8+ depletion were even greater than those in non-depleted mice. Depletion of both T cell subsets, however, completely abrogated immunostimulatory effects of PGM on PFC generation (primary and secondary response), as well as, on primary SRBC-unrelated antibody production, leaving unchanged only the increase of IgG in secondary response. Immunostimulatory effects and isotype switching to IgG1 and IgG2a correlated with the changes in splenic CD4+, CD8+, CD5+ cells, pointing to the regulatory role of these cells and/or their cytokines in PGM-Zn induced immunostimulation. Altogether the data suggest that PGM-Zn may potentiate the co-stimulatory signals coming from activated T cells and act on B cells without the T-cell help.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaInternational archives of allergy and immunology
Brojčani podacivol. 119, br. 1, str. 13-22
p-ISSN1018-2438
DOIhttps://doi.org/10.1159/000024170
URN:NBNurn:nbn:hr:184:533296
Datum objave publikacije1999
URL dokumentahttp://bib.irb.hr/15495
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2023-01-16 12:53:12