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Scientific paper - Original scientific paper
On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc
International archives of allergy and immunology, 119 (1999), 1; 13-22. https://doi.org/10.1159/000024170
Ravlić Gulan, Jagoda; Radošević-Stašić, Biserka; Trobonjača, Zlatko; Petković, Marija; Ćuk, Mira; Rukavina, Daniel

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Ravlić Gulan, J., Radošević Stašić, B., Trobonjača, Z., Petković, M., Ćuk, M. & Rukavina, D. (1999). On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc. International archives of allergy and immunology, 119. (1), 13-22. doi: 10.1159/000024170

Ravlić Gulan, Jagoda, et al. "On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc." International archives of allergy and immunology, vol. 119, no. 1, 1999, pp. 13-22. https://doi.org/10.1159/000024170

Ravlić Gulan, Jagoda, Biserka Radošević Stašić, Zlatko Trobonjača, Marija Petković, Mira Ćuk and Daniel Rukavina. "On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc." International archives of allergy and immunology 119, no. 1 (1999): 13-22. https://doi.org/10.1159/000024170

Ravlić Gulan, J., et al. (1999) 'On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc', International archives of allergy and immunology, 119(1), pp. 13-22. doi: 10.1159/000024170

Ravlić Gulan J, Radošević Stašić B, Trobonjača Z, Petković M, Ćuk M, Rukavina D. On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc. International archives of allergy and immunology [Internet]. 1999 [cited 2024 December 11];119(1):13-22. doi: 10.1159/000024170

J. Ravlić Gulan, B. Radošević Stašić, Z. Trobonjača, M. Petković, M. Ćuk and D. Rukavina, "On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc", International archives of allergy and immunology, vol. 119, no. 1, pp. 13-22, 1999. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:533296. [Accessed: 11 December 2024]

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Metadata
Title (english)On the role of T lymphocytes in stimulation of humoral immunity induced by peptidoglycan-monomer linked with zinc
AuthorJagoda Ravlić Gulan
AuthorBiserka Radošević-Stašić
AuthorZlatko Trobonjača
AuthorMarija Petković
AuthorMira Ćuk
AuthorDaniel Rukavina
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Effects of peptidoglycan linked with zinc (PGM-Zn) were investigated on PFC-generation to SRBC and SRBC-unrelated antibody production in primary and secondary immune response in mice depleted in vivo of CD4+ and/or CD8+ T lymphocytes. PGM-Zn in non-depleted mice stimulated the PFC generation and IgM or IgG and IgG1 production in primary and secondary reaction. Single depletion of CD4 or CD8+ T cells did not change this ability. The effects of PGM-Zn after CD8+ depletion were even greater than those in non-depleted mice. Depletion of both T cell subsets, however, completely abrogated immunostimulatory effects of PGM on PFC generation (primary and secondary response), as well as, on primary SRBC-unrelated antibody production, leaving unchanged only the increase of IgG in secondary response. Immunostimulatory effects and isotype switching to IgG1 and IgG2a correlated with the changes in splenic CD4+, CD8+, CD5+ cells, pointing to the regulatory role of these cells and/or their cytokines in PGM-Zn induced immunostimulation. Altogether the data suggest that PGM-Zn may potentiate the co-stimulatory signals coming from activated T cells and act on B cells without the T-cell help.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleInternational archives of allergy and immunology
Numberingvol. 119, no. 1, pp. 13-22
p-ISSN1018-2438
DOIhttps://doi.org/10.1159/000024170
URN:NBNurn:nbn:hr:184:533296
Publication1999
Document URLhttp://bib.irb.hr/15495
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2023-01-16 12:53:12