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Modeling Central Nervous System Injury In Vitro: Current Status and Promising Future Strategies
Biomedicines, 11 (2023), 1; 94. https://doi.org/10.3390/biomedicines11010094
Pilipović, Kristina; Harej Hrkać, Anja; Kučić, Natalia; Mršić-Pelčić, Jasenka

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Pilipović, K., Harej Hrkać, A., Kučić, N. i Mršić Pelčić, J. (2023). Modeling Central Nervous System Injury In Vitro: Current Status and Promising Future Strategies. Biomedicines, 11. (1). doi: 10.3390/biomedicines11010094

Pilipović, Kristina, et al. "Modeling Central Nervous System Injury In Vitro: Current Status and Promising Future Strategies." Biomedicines, vol. 11, br. 1, 2023. https://doi.org/10.3390/biomedicines11010094

Pilipović, Kristina, Anja Harej Hrkać, Natalia Kučić i Jasenka Mršić Pelčić. "Modeling Central Nervous System Injury In Vitro: Current Status and Promising Future Strategies." Biomedicines 11, br. 1 (2023). https://doi.org/10.3390/biomedicines11010094

Pilipović, K., et al. (2023) 'Modeling Central Nervous System Injury In Vitro: Current Status and Promising Future Strategies', Biomedicines, 11(1). doi: 10.3390/biomedicines11010094

Pilipović K, Harej Hrkać A, Kučić N, Mršić Pelčić J. Modeling Central Nervous System Injury In Vitro: Current Status and Promising Future Strategies. Biomedicines [Internet]. 2023. [pristupljeno 21.10.2024.];11(1). doi: 10.3390/biomedicines11010094

K. Pilipović, A. Harej Hrkać, N. Kučić i J. Mršić Pelčić, "Modeling Central Nervous System Injury In Vitro: Current Status and Promising Future Strategies", Biomedicines, vol. 11, br. 1, 2023. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:436061. [Citirano: 21.10.2024.]

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Podaci o radu
Naslov (engleski)Modeling Central Nervous System Injury In Vitro: Current Status and Promising Future Strategies
AutorKristina Pilipović
AutorAnja Harej Hrkać
AutorNatalia Kučić
MBZ: 239812
AutorJasenka Mršić-Pelčić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za farmakologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Farmakologija
Sažetak (engleski)
The central nervous system (CNS) injury, which occurs because of mechanical trauma or ischemia/hypoxia, is one of the main causes of mortality and morbidity in the modern society. Until know, despite the fact that numerous preclinical and clinical studies have been undertaken, no significant neuroprotective strategies have been discovered that could be used in the brain trauma or ischemia treatment. Although there are many potential explanations for the failure of those studies, it is clear that there are questions regarding the use of experimental models, both in vivo and in vitro, when studying CNS injury and searching new therapeutics. Due to some ethical issues with the use of live animals in biomedical research, implementation of experimental strategies that prioritize the use of cells and tissues in the in vitro environment has been encouraged. In this review, we examined some of the most commonly used in vitro models and the most frequently utilized cellular platforms in the research of traumatic brain injury and cerebral ischemia. We also proposed some future strategies that could improve the usefulness of these studies for better bench-to-bedside translational outcomes.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaBiomedicines
Brojčani podacivol. 11, br. 1, 94
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines11010094
URN:NBNurn:nbn:hr:184:436061
Datum objave elektroničkog izdanja2023
ProjektŠifra: uniri-biomed-18-115
Naziv (hrvatski): Molekularni mehanizmi ishemijskog oštećenja mozga i neuroprotekcija
Naziv (engleski): Molecular mechanisms of ischemic brain damage and neuroprotection
Voditelj: Jasenka Mršić-Pelčić
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Nema
ProjektŠifra: uniri-biomed-18-199
Naziv (hrvatski): Molekularni mehanizmi neurodegeneracije u traumatskoj ozljedi mozga: uloga TAR DNA-vezujućeg proteina 43
Naziv (engleski): Molecular mechanisms of neurodegeneration in traumatic brain injury: the role of TAR DNA-binding protein 43
Voditelj: Kristina Pilipović
Pravna nadležnost: Hrvatska
Financijer: NadSve
Linija financiranja: Nema
ProjektŠifra: UIP-2017-05-9517
Naziv (hrvatski): Jednozidne ugljikove nanocjevčice u eksperimentalnoj traumatskoj ozljedi mozga
Naziv (engleski): Single walled carbon nanotubes in experimental traumatic brain injury
Kratica: CarNanoTBI
Voditelj: Kristina Pilipović
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: UIP
URL dokumentahttps://www.mdpi.com/2227-9059/11/1/94
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2023-01-10 13:26:14