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Scientific paper - Original scientific paper
Modeling Central Nervous System Injury In Vitro: Current Status and Promising Future Strategies
Biomedicines, 11 (2023), 1; 94. https://doi.org/10.3390/biomedicines11010094
Pilipović, Kristina; Harej Hrkać, Anja; Kučić, Natalia; Mršić-Pelčić, Jasenka

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Pilipović, K., Harej Hrkać, A., Kučić, N. & Mršić Pelčić, J. (2023). Modeling Central Nervous System Injury In Vitro: Current Status and Promising Future Strategies. Biomedicines, 11. (1). doi: 10.3390/biomedicines11010094

Pilipović, Kristina, et al. "Modeling Central Nervous System Injury In Vitro: Current Status and Promising Future Strategies." Biomedicines, vol. 11, no. 1, 2023. https://doi.org/10.3390/biomedicines11010094

Pilipović, Kristina, Anja Harej Hrkać, Natalia Kučić and Jasenka Mršić Pelčić. "Modeling Central Nervous System Injury In Vitro: Current Status and Promising Future Strategies." Biomedicines 11, no. 1 (2023). https://doi.org/10.3390/biomedicines11010094

Pilipović, K., et al. (2023) 'Modeling Central Nervous System Injury In Vitro: Current Status and Promising Future Strategies', Biomedicines, 11(1). doi: 10.3390/biomedicines11010094

Pilipović K, Harej Hrkać A, Kučić N, Mršić Pelčić J. Modeling Central Nervous System Injury In Vitro: Current Status and Promising Future Strategies. Biomedicines [Internet]. 2023 [cited 2024 November 16];11(1). doi: 10.3390/biomedicines11010094

K. Pilipović, A. Harej Hrkać, N. Kučić and J. Mršić Pelčić, "Modeling Central Nervous System Injury In Vitro: Current Status and Promising Future Strategies", Biomedicines, vol. 11, no. 1, 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:436061. [Accessed: 16 November 2024]

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Metadata
Title (english)Modeling Central Nervous System Injury In Vitro: Current Status and Promising Future Strategies
AuthorKristina Pilipović
AuthorAnja Harej Hrkać
AuthorNatalia Kučić
MBZ: 239812
AuthorJasenka Mršić-Pelčić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
The central nervous system (CNS) injury, which occurs because of mechanical trauma or ischemia/hypoxia, is one of the main causes of mortality and morbidity in the modern society. Until know, despite the fact that numerous preclinical and clinical studies have been undertaken, no significant neuroprotective strategies have been discovered that could be used in the brain trauma or ischemia treatment. Although there are many potential explanations for the failure of those studies, it is clear that there are questions regarding the use of experimental models, both in vivo and in vitro, when studying CNS injury and searching new therapeutics. Due to some ethical issues with the use of live animals in biomedical research, implementation of experimental strategies that prioritize the use of cells and tissues in the in vitro environment has been encouraged. In this review, we examined some of the most commonly used in vitro models and the most frequently utilized cellular platforms in the research of traumatic brain injury and cerebral ischemia. We also proposed some future strategies that could improve the usefulness of these studies for better bench-to-bedside translational outcomes.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 11, no. 1, 94
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines11010094
URN:NBNurn:nbn:hr:184:436061
Online first2023
ProjectNumber: uniri-biomed-18-115
Title (croatian): Molekularni mehanizmi ishemijskog oštećenja mozga i neuroprotekcija
Title (english): Molecular mechanisms of ischemic brain damage and neuroprotection
Leader: Jasenka Mršić-Pelčić
Jurisdiction: Croatia
Funding stream: Nema
ProjectNumber: uniri-biomed-18-199
Title (croatian): Molekularni mehanizmi neurodegeneracije u traumatskoj ozljedi mozga: uloga TAR DNA-vezujućeg proteina 43
Title (english): Molecular mechanisms of neurodegeneration in traumatic brain injury: the role of TAR DNA-binding protein 43
Leader: Kristina Pilipović
Jurisdiction: Croatia
Funding stream: Nema
ProjectNumber: UIP-2017-05-9517
Title (croatian): Jednozidne ugljikove nanocjevčice u eksperimentalnoj traumatskoj ozljedi mozga
Title (english): Single walled carbon nanotubes in experimental traumatic brain injury
Acronym: CarNanoTBI
Leader: Kristina Pilipović
Jurisdiction: Croatia
Funding stream: UIP
Document URLhttps://www.mdpi.com/2227-9059/11/1/94
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-01-10 13:26:14