prikaz prve stranice dokumenta Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis
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Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis
Journal of Orthopaedic Research, 37 (2019), 9; 1972-1978. https://doi.org/10.1002/jor.24334
Eftedal, RandiK; Vrgoc, Goran; Jotanovic, Zdravko; Dembic, Zlatko

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Eftedal, R., Vrgoc, G., Jotanovic, Z. i Dembic, Z. (2019). Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis. Journal of Orthopaedic Research, 37. (9), 1972-1978. doi: 10.1002/jor.24334

Eftedal, RandiK, et al. "Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis." Journal of Orthopaedic Research, vol. 37, br. 9, 2019, str. 1972-1978. https://doi.org/10.1002/jor.24334

Eftedal, RandiK, Goran Vrgoc, Zdravko Jotanovic i Zlatko Dembic. "Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis." Journal of Orthopaedic Research 37, br. 9 (2019): 1972-1978. https://doi.org/10.1002/jor.24334

Eftedal, R., et al. (2019) 'Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis', Journal of Orthopaedic Research, 37(9), str. 1972-1978. doi: 10.1002/jor.24334

Eftedal R, Vrgoc G, Jotanovic Z, Dembic Z. Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis. Journal of Orthopaedic Research [Internet]. 20.05.2019. [pristupljeno 24.12.2024.];37(9):1972-1978. doi: 10.1002/jor.24334

R. Eftedal, G. Vrgoc, Z. Jotanovic i Z. Dembic, "Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis", Journal of Orthopaedic Research, vol. 37, br. 9, str. 1972-1978, Svibanj 2019. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:723011. [Citirano: 24.12.2024.]

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Naslov (engleski)Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis
AutorRandiK Eftedal
AutorGoran Vrgoc
AutorZdravko Jotanovic
AutorZlatko Dembic
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Ortopedija
Sažetak (engleski)
We studied the genetic epidemiology of primary large‐joint (hip and knee) osteoarthritis (OA), in order to find disease riskfactors by a candidate‐gene approach. We used case–control study in the Croatian Caucasian population. We genotyped 500 OA patients(260 hip, 240 knee; both with total joint replacements) and 597 healthy individuals for single‐nucleotide polymorphisms (SNPs) ininterleukin 17A (IL17A) (rs2275913) and IL17F (rs763780 and rs1889570) genes. On the basis of our population and allelic and genotypicfrequencies haplotypes were predicted by PHASE software and compared between patients and controls. The three‐SNP haplotype(rs2275913–rs763780–rs1889570) G–C–A confers predisposition to hip (p<0.005) but not knee OA. The three‐SNP haplotype havingopposed nucleotides A–T–G was found significantly associated with 2.6 times higher risk for developing knee (p<0.02) but not hip OA.ThehaplotypeG–T (IL17A–IL17F; rs2275913–rs763780) is associated with protection to the disease in hip OA (p<0.01). Our analysesshow that two disparate haplotypes within the IL17A‐F gene locus are associated with higher risk to developing hip and knee OA in theCroatian population. The data might suggest a difference in the etiology of hip OA from that of the knee OA, perhaps due to an unknowndissimilarity in vulnerability of these joints to the actions of IL17. Alternatively, other differences in genetic factors like the long non‐protein coding region LINCMD1 and/or microRNA species like miR133b and miR206 found in the vicinity of the IL17 locus might beinvolved in the observed risk.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Orthopaedic Research
Brojčani podacivol. 37, br. 9, str. 1972-1978
p-ISSN0736-0266
e-ISSN1554-527X
DOIhttps://doi.org/10.1002/jor.24334
URN:NBNurn:nbn:hr:184:723011
Datum objave publikacije2019-05-20
URL dokumentahttps://onlinelibrary.wiley.com/doi/10.1002/jor.24334
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-10-27 12:50:07