prikaz prve stranice dokumenta Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis
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Scientific paper - Original scientific paper
Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis
Journal of Orthopaedic Research, 37 (2019), 9; 1972-1978. https://doi.org/10.1002/jor.24334
Eftedal, RandiK; Vrgoc, Goran; Jotanovic, Zdravko; Dembic, Zlatko

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Eftedal, R., Vrgoc, G., Jotanovic, Z. & Dembic, Z. (2019). Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis. Journal of Orthopaedic Research, 37. (9), 1972-1978. doi: 10.1002/jor.24334

Eftedal, RandiK, et al. "Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis." Journal of Orthopaedic Research, vol. 37, no. 9, 2019, pp. 1972-1978. https://doi.org/10.1002/jor.24334

Eftedal, RandiK, Goran Vrgoc, Zdravko Jotanovic and Zlatko Dembic. "Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis." Journal of Orthopaedic Research 37, no. 9 (2019): 1972-1978. https://doi.org/10.1002/jor.24334

Eftedal, R., et al. (2019) 'Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis', Journal of Orthopaedic Research, 37(9), pp. 1972-1978. doi: 10.1002/jor.24334

Eftedal R, Vrgoc G, Jotanovic Z, Dembic Z. Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis. Journal of Orthopaedic Research [Internet]. 2019 May 20 [cited 2024 December 25];37(9):1972-1978. doi: 10.1002/jor.24334

R. Eftedal, G. Vrgoc, Z. Jotanovic and Z. Dembic, "Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis", Journal of Orthopaedic Research, vol. 37, no. 9, pp. 1972-1978, May 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:723011. [Accessed: 25 December 2024]

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Metadata
Title (english)Alternative Interleukin 17A/F Locus Haplotypes Are Associated With Increased Risk to Hip and Knee Osteoarthritis
AuthorRandiK Eftedal
AuthorGoran Vrgoc
AuthorZdravko Jotanovic
AuthorZlatko Dembic
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Orthopedics
Abstract (english)
We studied the genetic epidemiology of primary large‐joint (hip and knee) osteoarthritis (OA), in order to find disease riskfactors by a candidate‐gene approach. We used case–control study in the Croatian Caucasian population. We genotyped 500 OA patients(260 hip, 240 knee; both with total joint replacements) and 597 healthy individuals for single‐nucleotide polymorphisms (SNPs) ininterleukin 17A (IL17A) (rs2275913) and IL17F (rs763780 and rs1889570) genes. On the basis of our population and allelic and genotypicfrequencies haplotypes were predicted by PHASE software and compared between patients and controls. The three‐SNP haplotype(rs2275913–rs763780–rs1889570) G–C–A confers predisposition to hip (p<0.005) but not knee OA. The three‐SNP haplotype havingopposed nucleotides A–T–G was found significantly associated with 2.6 times higher risk for developing knee (p<0.02) but not hip OA.ThehaplotypeG–T (IL17A–IL17F; rs2275913–rs763780) is associated with protection to the disease in hip OA (p<0.01). Our analysesshow that two disparate haplotypes within the IL17A‐F gene locus are associated with higher risk to developing hip and knee OA in theCroatian population. The data might suggest a difference in the etiology of hip OA from that of the knee OA, perhaps due to an unknowndissimilarity in vulnerability of these joints to the actions of IL17. Alternatively, other differences in genetic factors like the long non‐protein coding region LINCMD1 and/or microRNA species like miR133b and miR206 found in the vicinity of the IL17 locus might beinvolved in the observed risk.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Orthopaedic Research
Numberingvol. 37, no. 9, pp. 1972-1978
p-ISSN0736-0266
e-ISSN1554-527X
DOIhttps://doi.org/10.1002/jor.24334
URN:NBNurn:nbn:hr:184:723011
Publication2019-05-20
Document URLhttps://onlinelibrary.wiley.com/doi/10.1002/jor.24334
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-10-27 12:50:07