prikaz prve stranice dokumenta Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern
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Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern
iScience, 25 (2022), 9; 104935. https://doi.org/10.1016/j.isci.2022.104935
Chaouat, Abigael E.; Brizić, Ilija; Kučan Brlić, Paola; Atari, Nofar; Kliker, Limor; Alfi, Or; Mandelboim, Michal; Wolf, Dana; Tafish, Laith; Kol, Inbal; Jonjić, Stipan; Mandelboim, Ofer

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Chaouat, A. E., Brizić, I., Kučan Brlić, P., Atari, N., Kliker, L., Alfi, O. ... Mandelboim, O. (2022). Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern. iScience, 25. (9). doi: 10.1016/j.isci.2022.104935

Chaouat, Abigael E., et al. "Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern." iScience, vol. 25, br. 9, 2022. https://doi.org/10.1016/j.isci.2022.104935

Chaouat, Abigael E., Ilija Brizić, Paola Kučan Brlić, Nofar Atari, Limor Kliker, Or Alfi, Michal Mandelboim, et al. "Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern." iScience 25, br. 9 (2022). https://doi.org/10.1016/j.isci.2022.104935

Chaouat, A. E., et al. (2022) 'Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern', iScience, 25(9). doi: 10.1016/j.isci.2022.104935

Chaouat AE, Brizić I, Kučan Brlić P, Atari N, Kliker L, Alfi O, i sur.. Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern. iScience [Internet]. 09.2022. [pristupljeno 13.11.2024.];25(9). doi: 10.1016/j.isci.2022.104935

A. E. Chaouat, et al., "Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern", iScience, vol. 25, br. 9, Rujan 2022. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:257342. [Citirano: 13.11.2024.]

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Naslov (engleski)Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern
AutorAbigael E. Chaouat
AutorIlija Brizić
AutorPaola Kučan Brlić
AutorNofar Atari
AutorLimor Kliker
AutorOr Alfi
AutorMichal Mandelboim
AutorDana Wolf
AutorLaith Tafish
AutorInbal Kol
AutorStipan Jonjić
AutorOfer Mandelboim
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The global pandemic caused by SARS-CoV-2 is a major public health problem. Virus entry occurs via binding to ACE2. Five SARS-CoV-2 variants of concern (VOCs) were reported so far, all having immune escape characteristics. Infection with the current VOC Omicron was noticed in immunized and recovered individuals; therefore, the development of new treatments against VOC infections is urgently needed. Most approved mAbs treatments against SARS-CoV-2 are directed against the spike protein of the original virus and are therefore inefficient against Omicron. Here, we report on the generation of hACE2.16, an anti-ACE2 antibody that recognizes and blocks ACE2-RBD binding without affecting ACE2 enzymatic activity. We demonstrate that hACE2.16 binding to ACE2 does not affect its surface expression and that hACE2.16 blocks infection and virus production of various VOCs including Omicron BA.1 and BA.2. hACE2.16 might, therefore, be an efficient treatment against all VOCs, the current and probably also future ones.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaiScience
Brojčani podacivol. 25, br. 9, 104935
p-ISSN2589-0042
DOIhttps://doi.org/10.1016/j.isci.2022.104935
URN:NBNurn:nbn:hr:184:257342
Datum objave publikacije2022-09
ProjektŠifra: IP-CORONA-2020-04-2073
Naziv (hrvatski): Dosta skrivanja CoV-2: uspostava baze monoklonskih protutijela na SARS-Cov-2
Naziv (engleski): No more hiding CoV-2: Establishment of SARS-Cov-2 mAbeom
Kratica: CoV2mAbs
Voditelj: Ilija Brizić
Pravna nadležnost: Hrvatska
Financijer: HRZZ
Linija financiranja: IP-CORONA
URL dokumentahttps://linkinghub.elsevier.com/retrieve/pii/S258900422201207X
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Bez prerada 4.0 međunarodna (CC BY-NC-ND 4.0)
Datum i vrijeme pohrane2022-09-21 12:10:26