prikaz prve stranice dokumenta Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern
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Scientific paper - Original scientific paper
Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern
iScience, 25 (2022), 9; 104935. https://doi.org/10.1016/j.isci.2022.104935
Chaouat, Abigael E.; Brizić, Ilija; Kučan Brlić, Paola; Atari, Nofar; Kliker, Limor; Alfi, Or; Mandelboim, Michal; Wolf, Dana; Tafish, Laith; Kol, Inbal; Jonjić, Stipan; Mandelboim, Ofer

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Chaouat, A. E., Brizić, I., Kučan Brlić, P., Atari, N., Kliker, L., Alfi, O. ... Mandelboim, O. (2022). Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern. iScience, 25. (9). doi: 10.1016/j.isci.2022.104935

Chaouat, Abigael E., et al. "Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern." iScience, vol. 25, no. 9, 2022. https://doi.org/10.1016/j.isci.2022.104935

Chaouat, Abigael E., Ilija Brizić, Paola Kučan Brlić, Nofar Atari, Limor Kliker, Or Alfi, Michal Mandelboim, et al. "Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern." iScience 25, no. 9 (2022). https://doi.org/10.1016/j.isci.2022.104935

Chaouat, A. E., et al. (2022) 'Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern', iScience, 25(9). doi: 10.1016/j.isci.2022.104935

Chaouat AE, Brizić I, Kučan Brlić P, Atari N, Kliker L, Alfi O, and sur.. Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern. iScience [Internet]. 2022 September [cited 2024 November 17];25(9). doi: 10.1016/j.isci.2022.104935

A. E. Chaouat, et al., "Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern", iScience, vol. 25, no. 9, September 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:257342. [Accessed: 17 November 2024]

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Metadata
Title (english)Anti-human ACE2 antibody neutralizes and inhibits virus production of SARS-CoV-2 variants of concern
AuthorAbigael E. Chaouat
AuthorIlija Brizić
AuthorPaola Kučan Brlić
AuthorNofar Atari
AuthorLimor Kliker
AuthorOr Alfi
AuthorMichal Mandelboim
AuthorDana Wolf
AuthorLaith Tafish
AuthorInbal Kol
AuthorStipan Jonjić
AuthorOfer Mandelboim
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The global pandemic caused by SARS-CoV-2 is a major public health problem. Virus entry occurs via binding to ACE2. Five SARS-CoV-2 variants of concern (VOCs) were reported so far, all having immune escape characteristics. Infection with the current VOC Omicron was noticed in immunized and recovered individuals; therefore, the development of new treatments against VOC infections is urgently needed. Most approved mAbs treatments against SARS-CoV-2 are directed against the spike protein of the original virus and are therefore inefficient against Omicron. Here, we report on the generation of hACE2.16, an anti-ACE2 antibody that recognizes and blocks ACE2-RBD binding without affecting ACE2 enzymatic activity. We demonstrate that hACE2.16 binding to ACE2 does not affect its surface expression and that hACE2.16 blocks infection and virus production of various VOCs including Omicron BA.1 and BA.2. hACE2.16 might, therefore, be an efficient treatment against all VOCs, the current and probably also future ones.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleiScience
Numberingvol. 25, no. 9, 104935
p-ISSN2589-0042
DOIhttps://doi.org/10.1016/j.isci.2022.104935
URN:NBNurn:nbn:hr:184:257342
Publication2022-09
ProjectNumber: IP-CORONA-2020-04-2073
Title (croatian): Dosta skrivanja CoV-2: uspostava baze monoklonskih protutijela na SARS-Cov-2
Title (english): No more hiding CoV-2: Establishment of SARS-Cov-2 mAbeom
Acronym: CoV2mAbs
Leader: Ilija Brizić
Jurisdiction: Croatia
Funding stream: IP-CORONA
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S258900422201207X
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-09-21 12:10:26