prikaz prve stranice dokumenta Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?
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Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?
Acta Dermatovenerologica Croatica, 29 (2021), 1; 30-34. urn:nbn:hr:184:354497
Čabrijan, Leo; Lipozenčić, Jasna

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Čabrijan, L. i Lipozenčić, J. (2021). Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?. Acta Dermatovenerologica Croatica, 29. (1), 30-34. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:354497

Čabrijan, Leo i Jasna Lipozenčić. "Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?." Acta Dermatovenerologica Croatica, vol. 29, br. 1, 2021, str. 30-34. https://urn.nsk.hr/urn:nbn:hr:184:354497

Čabrijan, Leo i Jasna Lipozenčić. "Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?." Acta Dermatovenerologica Croatica 29, br. 1 (2021): 30-34. https://urn.nsk.hr/urn:nbn:hr:184:354497

Čabrijan, L. i Lipozenčić, J. (2021) 'Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?', Acta Dermatovenerologica Croatica, 29(1), str. 30-34. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:354497 (Datum pristupa: 05.12.2024.)

Čabrijan L, Lipozenčić J. Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?. Acta Dermatovenerologica Croatica [Internet]. 2021. [pristupljeno 05.12.2024.];29(1):30-34. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:354497

L. Čabrijan i J. Lipozenčić, "Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?", Acta Dermatovenerologica Croatica, vol. 29, br. 1, str. 30-34, 2021. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:354497. [Citirano: 05.12.2024.]

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Naslov (engleski)Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?
AutorLeo Čabrijan
AutorJasna Lipozenčić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za dermatovenerologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Dermatovenerologija
Sažetak (engleski)
The process of melanoma metastasis can be divided into two stages of metastatic cell dissemination and proliferation. The whole process should be observed and distinguished through the variable or prism of time. The fact that melanoma metastases are detected in visceral organs at the stage when they are macroscopically visible does not imply that their onset has occurred much earlier. Additionally, it is quite obvious that the entire process is not driven by melanoma but rather only the initial stage of metastatic cell dissemination, whereas the later stage of metastatic cell proliferation is driven by other factors, firstly by mutated genes in the presence of melanoma or without it. Dissemination of metastatic cells occurs at approximately the same time in all melanomas, at MIS transition to MM, but is not immediately followed by metastatic cell proliferation; instead, some time has to elapse for a particular gene mutation to occur, and this timing varies among melanomas. Following dissemination of metastatic cells to visceral organs, they remain inactive, and in this period the presence of melanoma is not necessary anymore for metastatic cell proliferation, as they are waiting for a signal to start multiplying. This is clearly discernible from the fact that melanoma is today detected and removed frequently and early, but visible metastases then develop in the absence of melanoma, which may also regress spontaneously. Accordingly, MM is no longer necessary for metastasis later on. Finally, let me rephrase the title: melanoma is only responsible for initial dissemination of metastatic cells, whereas subsequent proliferation of metastatic cells is driven by other factors, most probably mutated genes.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaActa Dermatovenerologica Croatica
Brojčani podacivol. 29, br. 1, str. 30-34
p-ISSN1330-027X
e-ISSN1847-6538
URN:NBNurn:nbn:hr:184:354497
Datum objave publikacije2021
URL dokumentahttps://hrcak.srce.hr/274440
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-29 12:21:35