prikaz prve stranice dokumenta Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?
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Scientific paper - Original scientific paper
Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?
Acta Dermatovenerologica Croatica, 29 (2021), 1; 30-34. urn:nbn:hr:184:354497
Čabrijan, Leo; Lipozenčić, Jasna

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Čabrijan, L. & Lipozenčić, J. (2021). Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?. Acta Dermatovenerologica Croatica, 29. (1), 30-34. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:354497

Čabrijan, Leo and Jasna Lipozenčić. "Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?." Acta Dermatovenerologica Croatica, vol. 29, no. 1, 2021, pp. 30-34. https://urn.nsk.hr/urn:nbn:hr:184:354497

Čabrijan, Leo and Jasna Lipozenčić. "Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?." Acta Dermatovenerologica Croatica 29, no. 1 (2021): 30-34. https://urn.nsk.hr/urn:nbn:hr:184:354497

Čabrijan, L. and Lipozenčić, J. (2021) 'Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?', Acta Dermatovenerologica Croatica, 29(1), pp. 30-34. Available at: https://urn.nsk.hr/urn:nbn:hr:184:354497 (Accessed 09 December 2024)

Čabrijan L, Lipozenčić J. Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?. Acta Dermatovenerologica Croatica [Internet]. 2021 [cited 2024 December 09];29(1):30-34. Available at: https://urn.nsk.hr/urn:nbn:hr:184:354497

L. Čabrijan and J. Lipozenčić, "Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?", Acta Dermatovenerologica Croatica, vol. 29, no. 1, pp. 30-34, 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:354497. [Accessed: 09 December 2024]

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Metadata
Title (english)Melanoma Controls the Metastatic Process only in Terms of Metastatic Cell Dissemination – What Is Responsible for Metastatic Cell Proliferation?
AuthorLeo Čabrijan
AuthorJasna Lipozenčić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (english)
The process of melanoma metastasis can be divided into two stages of metastatic cell dissemination and proliferation. The whole process should be observed and distinguished through the variable or prism of time. The fact that melanoma metastases are detected in visceral organs at the stage when they are macroscopically visible does not imply that their onset has occurred much earlier. Additionally, it is quite obvious that the entire process is not driven by melanoma but rather only the initial stage of metastatic cell dissemination, whereas the later stage of metastatic cell proliferation is driven by other factors, firstly by mutated genes in the presence of melanoma or without it. Dissemination of metastatic cells occurs at approximately the same time in all melanomas, at MIS transition to MM, but is not immediately followed by metastatic cell proliferation; instead, some time has to elapse for a particular gene mutation to occur, and this timing varies among melanomas. Following dissemination of metastatic cells to visceral organs, they remain inactive, and in this period the presence of melanoma is not necessary anymore for metastatic cell proliferation, as they are waiting for a signal to start multiplying. This is clearly discernible from the fact that melanoma is today detected and removed frequently and early, but visible metastases then develop in the absence of melanoma, which may also regress spontaneously. Accordingly, MM is no longer necessary for metastasis later on. Finally, let me rephrase the title: melanoma is only responsible for initial dissemination of metastatic cells, whereas subsequent proliferation of metastatic cells is driven by other factors, most probably mutated genes.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa Dermatovenerologica Croatica
Numberingvol. 29, no. 1, pp. 30-34
p-ISSN1330-027X
e-ISSN1847-6538
URN:NBNurn:nbn:hr:184:354497
Publication2021
Document URLhttps://hrcak.srce.hr/274440
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-03-29 12:21:35