prikaz prve stranice dokumenta Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background
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Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background
European Journal of Immunology, 32 (2002), 12; 3463-3471. urn:nbn:hr:184:658732
Hasan, Milena; Polić, Bojan; Bralić, Marina; Jonjić, Stipan; Rajewsky, Klaus

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Hasan, M., Polić, B., Bralić, M., Jonjić, S. i Rajewsky, K. (2002). Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background. European Journal of Immunology, 32. (12), 3463-3471. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:658732

Hasan, Milena, et al. "Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background." European Journal of Immunology, vol. 32, br. 12, 2002, str. 3463-3471. https://urn.nsk.hr/urn:nbn:hr:184:658732

Hasan, Milena, Bojan Polić, Marina Bralić, Stipan Jonjić i Klaus Rajewsky. "Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background." European Journal of Immunology 32, br. 12 (2002): 3463-3471. https://urn.nsk.hr/urn:nbn:hr:184:658732

Hasan, M., et al. (2002) 'Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background', European Journal of Immunology, 32(12), str. 3463-3471. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:658732 (Datum pristupa: 21.10.2024.)

Hasan M, Polić B, Bralić M, Jonjić S, Rajewsky K. Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background. European Journal of Immunology [Internet]. 2002. [pristupljeno 21.10.2024.];32(12):3463-3471. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:658732

M. Hasan, B. Polić, M. Bralić, S. Jonjić i K. Rajewsky, "Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background", European Journal of Immunology, vol. 32, br. 12, str. 3463-3471, 2002. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:658732. [Citirano: 21.10.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:658732
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Podaci o radu
Naslov (engleski)Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background
AutorMilena Hasan
AutorBojan Polić
AutorMarina Bralić
AutorStipan Jonjić
AutorKlaus Rajewsky
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The expression of the preB cell receptor (preBCR), composed of the mu chain, surrogate light chains and the Igalpha /Igbeta signal transduction unit, permits further differentiation of Bcell precursors. C57BL/6 mice homozygous for an inactivating mutation of the membrane exon of the mu chain gene (C57BL/6muMT/muMT)) cannot form a preBCR and are, consequently, devoid of mature B lymphocytes. Here we present evidence that the block of B cell development by the muMT mutation is incomplete in BALB/c mice. Unlike C57BL/6muMT/muMT), BALB/cmuMT/muMT) mice generate small numbers of mature B cells, accumulate plasma cells and produce high levels of all immunoglobulin isotypes, except IgM. The observed phenomenon seems to be controlled by a single genetic locus that is not linked to IgH.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEuropean Journal of Immunology
Brojčani podacivol. 32, br. 12, str. 3463-3471
p-ISSN0014-2980
e-ISSN1521-4141
URN:NBNurn:nbn:hr:184:658732
Datum objave publikacije2002
URL dokumentahttp://bib.irb.hr/102507
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-18 13:48:34