prikaz prve stranice dokumenta Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background
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Scientific paper - Original scientific paper
Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background
European Journal of Immunology, 32 (2002), 12; 3463-3471. urn:nbn:hr:184:658732
Hasan, Milena; Polić, Bojan; Bralić, Marina; Jonjić, Stipan; Rajewsky, Klaus

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Hasan, M., Polić, B., Bralić, M., Jonjić, S. & Rajewsky, K. (2002). Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background. European Journal of Immunology, 32. (12), 3463-3471. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:658732

Hasan, Milena, et al. "Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background." European Journal of Immunology, vol. 32, no. 12, 2002, pp. 3463-3471. https://urn.nsk.hr/urn:nbn:hr:184:658732

Hasan, Milena, Bojan Polić, Marina Bralić, Stipan Jonjić and Klaus Rajewsky. "Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background." European Journal of Immunology 32, no. 12 (2002): 3463-3471. https://urn.nsk.hr/urn:nbn:hr:184:658732

Hasan, M., et al. (2002) 'Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background', European Journal of Immunology, 32(12), pp. 3463-3471. Available at: https://urn.nsk.hr/urn:nbn:hr:184:658732 (Accessed 11 December 2024)

Hasan M, Polić B, Bralić M, Jonjić S, Rajewsky K. Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background. European Journal of Immunology [Internet]. 2002 [cited 2024 December 11];32(12):3463-3471. Available at: https://urn.nsk.hr/urn:nbn:hr:184:658732

M. Hasan, B. Polić, M. Bralić, S. Jonjić and K. Rajewsky, "Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background", European Journal of Immunology, vol. 32, no. 12, pp. 3463-3471, 2002. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:658732. [Accessed: 11 December 2024]

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Metadata
Title (english)Incomplete block of B cell development and immunoglobulin production in mice carrying the uMT mutation on the BALB/c background
AuthorMilena Hasan
AuthorBojan Polić
AuthorMarina Bralić
AuthorStipan Jonjić
AuthorKlaus Rajewsky
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The expression of the preB cell receptor (preBCR), composed of the mu chain, surrogate light chains and the Igalpha /Igbeta signal transduction unit, permits further differentiation of Bcell precursors. C57BL/6 mice homozygous for an inactivating mutation of the membrane exon of the mu chain gene (C57BL/6muMT/muMT)) cannot form a preBCR and are, consequently, devoid of mature B lymphocytes. Here we present evidence that the block of B cell development by the muMT mutation is incomplete in BALB/c mice. Unlike C57BL/6muMT/muMT), BALB/cmuMT/muMT) mice generate small numbers of mature B cells, accumulate plasma cells and produce high levels of all immunoglobulin isotypes, except IgM. The observed phenomenon seems to be controlled by a single genetic locus that is not linked to IgH.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleEuropean Journal of Immunology
Numberingvol. 32, no. 12, pp. 3463-3471
p-ISSN0014-2980
e-ISSN1521-4141
URN:NBNurn:nbn:hr:184:658732
Publication2002
Document URLhttp://bib.irb.hr/102507
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-03-18 13:48:34