prikaz prve stranice dokumenta The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study
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The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study
Pathology - Research and Practice, 216 (2020), 9; 153068. https://doi.org/10.1016/j.prp.2020.153068
Rajković-Molek, Koraljka; Mustać, Elvira; Avirović, Manuela; Georgev, Paula; Demaria, Martina; Aničić, Josip; Ban, Josipa; Babarović, Emina

Citirajte ovaj rad

Rajković Molek, K., Mustać, E., Avirović, M., Georgev, P., Demaria, M., Aničić, J. ... Babarović, E. (2020). The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study. Pathology - Research and Practice, 216. (9). doi: 10.1016/j.prp.2020.153068

Rajković Molek, Koraljka, et al. "The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study." Pathology - Research and Practice, vol. 216, br. 9, 2020. https://doi.org/10.1016/j.prp.2020.153068

Rajković Molek, Koraljka, Elvira Mustać, Manuela Avirović, Paula Georgev, Martina Demaria, Josip Aničić, Josipa Ban i Emina Babarović. "The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study." Pathology - Research and Practice 216, br. 9 (2020). https://doi.org/10.1016/j.prp.2020.153068

Rajković Molek, K., et al. (2020) 'The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study', Pathology - Research and Practice, 216(9). doi: 10.1016/j.prp.2020.153068

Rajković Molek K, Mustać E, Avirović M, Georgev P, Demaria M, Aničić J, i sur.. The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study. Pathology - Research and Practice [Internet]. 2020. [pristupljeno 13.11.2024.];216(9). doi: 10.1016/j.prp.2020.153068

K. Rajković Molek, et al., "The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study", Pathology - Research and Practice, vol. 216, br. 9, 2020. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:120843. [Citirano: 13.11.2024.]

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Podaci o radu
Naslov (engleski)The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study
AutorKoraljka Rajković-Molek
AutorElvira Mustać
AutorManuela Avirović
AutorPaula Georgev
AutorMartina Demaria
AutorJosip Aničić
AutorJosipa Ban
AutorEmina Babarović
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za opću patologiju i patološku anatomiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Patologija
Sažetak (engleski)
Breast cancer is a heterogeneous disease with different biological outcome and ability to acquire resistance to therapy. The calpain family of proteases and androgen receptor (AR) are implicated in breast cancer pathogenesis and progression and are potential targets for novel treatment regimens. The aim of this study was to investigate the expression of calpain-1 and AR in breast cancer and to correlate their expression with clinicopathological variables and prognosis of patients. In this study we enrolled 219 breast cancer patients with long term follow-up information available. Immunohistochemical methods on a tissue microarray were used to investigate expression of calpain-1 and AR in tumor cells. The expression of calpain-1 and AR both differed significantly between the tumor subtypes of patients (p = 0.002 and p = 0.042 respectively). High calpain-1 expression was associated with patient’s age over 50 years (p = 0.005) and positive ER status (p = 0.009), but not with other clinicopathological variables. Women with AR negative breast cancers were more likely to be older (p = 0.016), to have bigger tumors (p = 0.032), higher stage of the disease (p = 0.026), presence of exulceration (p = 0.017), negative ER status (p = 0.007) and higher Ki-67 proliferative index (p = 0.027). Calpain-1 expression was not associated with breast cancer specific overall survival in the total cohort of patients, however low calpain-1 expression was associated with adverse survival (p = 0.018) in triple negative subgroup of patients. Low calpain-1 expression was also associated with significantly shorter 5-year disease-free survival in total cohort of patients (p = 0.03). AR status was not associated with overall and disease-free survival of patients. This study has demonstrated that the expression of calpain-1 and androgen receptors are associated with important clinicopathological variables. The expression of calpain-1 was associated with improved disease-free survival of all analyzed patients and with improved overall survival of triple negative breast cancer patients.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaPathology - Research and Practice
Brojčani podacivol. 216, br. 9, 153068
p-ISSN0344-0338
DOIhttps://doi.org/10.1016/j.prp.2020.153068
URN:NBNurn:nbn:hr:184:120843
Datum objave publikacije2020
URL dokumentahttp://bib.irb.hr/1107473
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-10 18:00:16