prikaz prve stranice dokumenta The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study
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Scientific paper - Original scientific paper
The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study
Pathology - Research and Practice, 216 (2020), 9; 153068. https://doi.org/10.1016/j.prp.2020.153068
Rajković-Molek, Koraljka; Mustać, Elvira; Avirović, Manuela; Georgev, Paula; Demaria, Martina; Aničić, Josip; Ban, Josipa; Babarović, Emina

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Rajković Molek, K., Mustać, E., Avirović, M., Georgev, P., Demaria, M., Aničić, J. ... Babarović, E. (2020). The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study. Pathology - Research and Practice, 216. (9). doi: 10.1016/j.prp.2020.153068

Rajković Molek, Koraljka, et al. "The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study." Pathology - Research and Practice, vol. 216, no. 9, 2020. https://doi.org/10.1016/j.prp.2020.153068

Rajković Molek, Koraljka, Elvira Mustać, Manuela Avirović, Paula Georgev, Martina Demaria, Josip Aničić, Josipa Ban and Emina Babarović. "The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study." Pathology - Research and Practice 216, no. 9 (2020). https://doi.org/10.1016/j.prp.2020.153068

Rajković Molek, K., et al. (2020) 'The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study', Pathology - Research and Practice, 216(9). doi: 10.1016/j.prp.2020.153068

Rajković Molek K, Mustać E, Avirović M, Georgev P, Demaria M, Aničić J, and sur.. The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study. Pathology - Research and Practice [Internet]. 2020 [cited 2024 April 25];216(9). doi: 10.1016/j.prp.2020.153068

K. Rajković Molek, et al., "The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study", Pathology - Research and Practice, vol. 216, no. 9, 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:120843. [Accessed: 25 April 2024]

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Metadata
Title (english)The expression of calpain-1 and androgen receptor in breast cancer and their correlation with clinicopathological characteristics: An immunohistochemical retrospective study
AuthorKoraljka Rajković-Molek
AuthorElvira Mustać
AuthorManuela Avirović
AuthorPaula Georgev
AuthorMartina Demaria
AuthorJosip Aničić
AuthorJosipa Ban
AuthorEmina Babarović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
Breast cancer is a heterogeneous disease with different biological outcome and ability to acquire resistance to therapy. The calpain family of proteases and androgen receptor (AR) are implicated in breast cancer pathogenesis and progression and are potential targets for novel treatment regimens. The aim of this study was to investigate the expression of calpain-1 and AR in breast cancer and to correlate their expression with clinicopathological variables and prognosis of patients. In this study we enrolled 219 breast cancer patients with long term follow-up information available. Immunohistochemical methods on a tissue microarray were used to investigate expression of calpain-1 and AR in tumor cells. The expression of calpain-1 and AR both differed significantly between the tumor subtypes of patients (p = 0.002 and p = 0.042 respectively). High calpain-1 expression was associated with patient’s age over 50 years (p = 0.005) and positive ER status (p = 0.009), but not with other clinicopathological variables. Women with AR negative breast cancers were more likely to be older (p = 0.016), to have bigger tumors (p = 0.032), higher stage of the disease (p = 0.026), presence of exulceration (p = 0.017), negative ER status (p = 0.007) and higher Ki-67 proliferative index (p = 0.027). Calpain-1 expression was not associated with breast cancer specific overall survival in the total cohort of patients, however low calpain-1 expression was associated with adverse survival (p = 0.018) in triple negative subgroup of patients. Low calpain-1 expression was also associated with significantly shorter 5-year disease-free survival in total cohort of patients (p = 0.03). AR status was not associated with overall and disease-free survival of patients. This study has demonstrated that the expression of calpain-1 and androgen receptors are associated with important clinicopathological variables. The expression of calpain-1 was associated with improved disease-free survival of all analyzed patients and with improved overall survival of triple negative breast cancer patients.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePathology - Research and Practice
Numberingvol. 216, no. 9, 153068
p-ISSN0344-0338
DOIhttps://doi.org/10.1016/j.prp.2020.153068
URN:NBNurn:nbn:hr:184:120843
Publication2020
Document URLhttp://bib.irb.hr/1107473
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2022-03-10 18:00:16