prikaz prve stranice dokumenta Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers
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Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers
Clinical chemistry and laboratory medicine, 56 (2018), 5; 776-788. https://doi.org/10.1515/cclm-2017-0889
Nikolac Gabaj, Nora; Miler, Marijana; Vrtarić, Alen; Hemar, Marina; Filipi, Petra; Kocijančić, Marija; Šupak Smolčić, Vesna; Ćelap, Ivana; Šimundić, Ana-Maria

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Nikolac Gabaj, N., Miler, M., Vrtarić, A., Hemar, M., Filipi, P., Kocijančić, M. ... Šimundić, A. M. (2018). Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers. Clinical chemistry and laboratory medicine, 56. (5), 776-788. doi: 10.1515/cclm-2017-0889

Nikolac Gabaj, Nora, et al. "Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers." Clinical chemistry and laboratory medicine, vol. 56, br. 5, 2018, str. 776-788. https://doi.org/10.1515/cclm-2017-0889

Nikolac Gabaj, Nora, Marijana Miler, Alen Vrtarić, Marina Hemar, Petra Filipi, Marija Kocijančić, Vesna Šupak Smolčić, Ivana Ćelap i Ana Maria Šimundić. "Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers." Clinical chemistry and laboratory medicine 56, br. 5 (2018): 776-788. https://doi.org/10.1515/cclm-2017-0889

Nikolac Gabaj, N., et al. (2018) 'Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers', Clinical chemistry and laboratory medicine, 56(5), str. 776-788. doi: 10.1515/cclm-2017-0889

Nikolac Gabaj N, Miler M, Vrtarić A, Hemar M, Filipi P, Kocijančić M, i sur.. Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers. Clinical chemistry and laboratory medicine [Internet]. 2018. [pristupljeno 01.01.2025.];56(5):776-788. doi: 10.1515/cclm-2017-0889

N. Nikolac Gabaj, et al., "Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers", Clinical chemistry and laboratory medicine, vol. 56, br. 5, str. 776-788, 2018. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:516327. [Citirano: 01.01.2025.]

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Podaci o radu
Naslov (engleski)Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers
AutorNora Nikolac Gabaj
AutorMarijana Miler
AutorAlen Vrtarić
AutorMarina Hemar
AutorPetra Filipi
AutorMarija Kocijančić
AutorVesna Šupak Smolčić
AutorIvana Ćelap
AutorAna-Maria Šimundić
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za kliničko-laboratorijsku dijagnostiku)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku informatiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Kliničke medicinske znanosti
Klinička biokemija
Sažetak (engleski)
Introduction: The aim of our study was to perform verification of serum indices measurement on three clinical chemistry platforms. Materials and methods: This study was done on three analyzers: Abbott Architect c8000, Beckman Coulter AU5800 (BC) and Roche Cobas 6000 c501. Following analytical specifications were verified: precision (two patient samples), accuracy (sample with the highest concentration of interferent was serially diluted and measured values compared to theoretical values), comparability (120 patients samples) and cross reactivity (samples with increasing concentrations of interferent were divided in two aliquots and remaining interferents were added in each aliquot. Measurements were done before and after adding interferents). Results: Best results for precision were obtained for H index (0.72% to 2.08%). Accuracy for H index was acceptable for Cobas and BC, while on Architect, deviations in high concentration range were observed (y = 0.02 (0.01-0.07) + 1.07 (1.06- 1.08) x). All three analyzers showed acceptable results in evaluating accuracy of L index and unacceptable results for I index. H index was comparable between BC and both, Architect (Cohen ´s Kappa (95% CI) = 0.795 (0.692-0.898)) and Roche (Cohen´s Kappa (95% CI) = 0.825 (0.729- 0.922)), while Roche and Architect were not comparable. I index was not comparable between all analyzer combinations, while L index was only comparable between Abbott and BC. Cross reactivity analysis mostly showed that serum indices measurement is affected when combination of interferences is present. Conclusion: There is heterogeneity between analyzers in HIL quality performance. Verification of serum indices in routine work is necessary to establish analytical specifications.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaClinical chemistry and laboratory medicine
Brojčani podacivol. 56, br. 5, str. 776-788
p-ISSN1434-6621
DOIhttps://doi.org/10.1515/cclm-2017-0889
URN:NBNurn:nbn:hr:184:516327
Datum objave publikacije2018
URL dokumentahttp://bib.irb.hr/915543
Vrsta resursaTekst
Prava pristupaZatvoreni pristup
Uvjeti korištenjaIkona licence Zaštićeno autorskim pravom.
Datum i vrijeme pohrane2022-03-03 14:32:28