prikaz prve stranice dokumenta Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers
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Scientific paper - Original scientific paper
Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers
Clinical chemistry and laboratory medicine, 56 (2018), 5; 776-788. https://doi.org/10.1515/cclm-2017-0889
Nikolac Gabaj, Nora; Miler, Marijana; Vrtarić, Alen; Hemar, Marina; Filipi, Petra; Kocijančić, Marija; Šupak Smolčić, Vesna; Ćelap, Ivana; Šimundić, Ana-Maria

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Nikolac Gabaj, N., Miler, M., Vrtarić, A., Hemar, M., Filipi, P., Kocijančić, M. ... Šimundić, A. M. (2018). Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers. Clinical chemistry and laboratory medicine, 56. (5), 776-788. doi: 10.1515/cclm-2017-0889

Nikolac Gabaj, Nora, et al. "Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers." Clinical chemistry and laboratory medicine, vol. 56, no. 5, 2018, pp. 776-788. https://doi.org/10.1515/cclm-2017-0889

Nikolac Gabaj, Nora, Marijana Miler, Alen Vrtarić, Marina Hemar, Petra Filipi, Marija Kocijančić, Vesna Šupak Smolčić, Ivana Ćelap and Ana Maria Šimundić. "Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers." Clinical chemistry and laboratory medicine 56, no. 5 (2018): 776-788. https://doi.org/10.1515/cclm-2017-0889

Nikolac Gabaj, N., et al. (2018) 'Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers', Clinical chemistry and laboratory medicine, 56(5), pp. 776-788. doi: 10.1515/cclm-2017-0889

Nikolac Gabaj N, Miler M, Vrtarić A, Hemar M, Filipi P, Kocijančić M, and sur.. Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers. Clinical chemistry and laboratory medicine [Internet]. 2018 [cited 2025 January 02];56(5):776-788. doi: 10.1515/cclm-2017-0889

N. Nikolac Gabaj, et al., "Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers", Clinical chemistry and laboratory medicine, vol. 56, no. 5, pp. 776-788, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:516327. [Accessed: 02 January 2025]

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Title (english)Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers
AuthorNora Nikolac Gabaj
AuthorMarijana Miler
AuthorAlen Vrtarić
AuthorMarina Hemar
AuthorPetra Filipi
AuthorMarija Kocijančić
AuthorVesna Šupak Smolčić
AuthorIvana Ćelap
AuthorAna-Maria Šimundić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Clinical Laboratory Diagnostics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Medical Informatics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Clinical Biochemistry
Abstract (english)
Introduction: The aim of our study was to perform verification of serum indices measurement on three clinical chemistry platforms. Materials and methods: This study was done on three analyzers: Abbott Architect c8000, Beckman Coulter AU5800 (BC) and Roche Cobas 6000 c501. Following analytical specifications were verified: precision (two patient samples), accuracy (sample with the highest concentration of interferent was serially diluted and measured values compared to theoretical values), comparability (120 patients samples) and cross reactivity (samples with increasing concentrations of interferent were divided in two aliquots and remaining interferents were added in each aliquot. Measurements were done before and after adding interferents). Results: Best results for precision were obtained for H index (0.72% to 2.08%). Accuracy for H index was acceptable for Cobas and BC, while on Architect, deviations in high concentration range were observed (y = 0.02 (0.01-0.07) + 1.07 (1.06- 1.08) x). All three analyzers showed acceptable results in evaluating accuracy of L index and unacceptable results for I index. H index was comparable between BC and both, Architect (Cohen ´s Kappa (95% CI) = 0.795 (0.692-0.898)) and Roche (Cohen´s Kappa (95% CI) = 0.825 (0.729- 0.922)), while Roche and Architect were not comparable. I index was not comparable between all analyzer combinations, while L index was only comparable between Abbott and BC. Cross reactivity analysis mostly showed that serum indices measurement is affected when combination of interferences is present. Conclusion: There is heterogeneity between analyzers in HIL quality performance. Verification of serum indices in routine work is necessary to establish analytical specifications.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleClinical chemistry and laboratory medicine
Numberingvol. 56, no. 5, pp. 776-788
p-ISSN1434-6621
DOIhttps://doi.org/10.1515/cclm-2017-0889
URN:NBNurn:nbn:hr:184:516327
Publication2018
Document URLhttp://bib.irb.hr/915543
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2022-03-03 14:32:28