prikaz prve stranice dokumenta Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.
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Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.
Journal of Physiology and Biochemistry, 72 (2016), 3; 405-419. https://doi.org/10.1007/s13105-016-0491-7
Detel, Dijana; Buljević, Sunčica; Batičić Pučar, Lara; Kučić, Natalia; Pernjak Pugel, Ester; Varljen, Jadranka

Citirajte ovaj rad

Detel, D., Buljević, S., Batičić Pučar, L., Kučić, N., Pernjak Pugel, E. i Varljen, J. (2016). Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.. Journal of Physiology and Biochemistry, 72. (3), 405-419. doi: 10.1007/s13105-016-0491-7

Detel, Dijana, et al. "Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.." Journal of Physiology and Biochemistry, vol. 72, br. 3, 2016, str. 405-419. https://doi.org/10.1007/s13105-016-0491-7

Detel, Dijana, Sunčica Buljević, Lara Batičić Pučar, Natalia Kučić, Ester Pernjak Pugel i Jadranka Varljen. "Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.." Journal of Physiology and Biochemistry 72, br. 3 (2016): 405-419. https://doi.org/10.1007/s13105-016-0491-7

Detel, D., et al. (2016) 'Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.', Journal of Physiology and Biochemistry, 72(3), str. 405-419. doi: 10.1007/s13105-016-0491-7

Detel D, Buljević S, Batičić Pučar L, Kučić N, Pernjak Pugel E, Varljen J. Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.. Journal of Physiology and Biochemistry [Internet]. 2016. [pristupljeno 25.12.2024.];72(3):405-419. doi: 10.1007/s13105-016-0491-7

D. Detel, S. Buljević, L. Batičić Pučar, N. Kučić, E. Pernjak Pugel i J. Varljen, "Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.", Journal of Physiology and Biochemistry, vol. 72, br. 3, str. 405-419, 2016. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:230306. [Citirano: 25.12.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:230306
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Naslov (engleski)Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.
AutorDijana Detel
AutorSunčica Buljević
AutorLara Batičić Pučar
AutorNatalia Kučić
MBZ: 239812
AutorEster Pernjak Pugel
AutorJadranka Varljen
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za histologiju i embriologiju)
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za medicinsku kemiju, biokemiju i kliničku kemiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Medicinska biokemija
Sažetak (engleski)
A lot of evidence for the importance of CD26/dipeptidyl peptidase IV (CD26/DPP IV) in immunoactivation has been reported ; however, its involvement in colitis remains unclear. The aim of this study was to investigate the influence of CD26/DPP IV deficiency on immunophenotypic changes associated with dextran sulfate sodium (DSS)-induced colitis in wild- type (WT) and CD26-deficient mice. Development of clinical symptoms of colitis and animal health status parameters were assessed ; the expression of the nuclear factor (NF)-κB p65 subunit was measured by quantitative real-time PCR, while cell characterization was determined by flow cytometry and immunohistochemical staining. DSS treatment induced loss of body weight and colon length shortening in both mouse strains. An increase of myeloperoxidase activity in CD26-deficient mice was more intensive than in WT mice, in spite of similar histopathological changes. Furthermore, a significant increase in the expression of NF-κB p65 subunit in the colon of CD26-deficient mice was determined. The percentage of splenic CD4+ and CD8+ cells in the acute phase of colitis was significantly decreased in WT mice, while in the same period, an increase in the percentage of splenic CD8+ cells was present in CD26-deficient mice. Development of colitis was accompanied by a significant increase in the percentage of intrahepatic NKT cells in both mouse strains, but their percentage in spleen was increased only in CD26-deficient mice. CD26 deficiency was associated with a heightened response to DSS accompanied by increased expression of NF-κB p65 subunit and distinct changes in leukocyte trafficking. These results provide new insights into the role of CD26/DPP IV during the development of colitis.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of Physiology and Biochemistry
Brojčani podacivol. 72, br. 3, str. 405-419
p-ISSN1138-7548
DOIhttps://doi.org/10.1007/s13105-016-0491-7
URN:NBNurn:nbn:hr:184:230306
Datum objave publikacije2016
ProjektŠifra: 062-0061245-0213
Naziv (hrvatski): Uloga dipeptidil-peptidaze IV (CD26/DPP IV) u kroničnim bolestima
Naziv (engleski): The role of dipeptidyl peptidase IV (CD26/DPP IV) in chronic diseases
Voditelj: Jadranka Varljen
Pravna nadležnost: Hrvatska
Financijer: MZOS
Linija financiranja: ZP
URL dokumentahttp://bib.irb.hr/820380
Vrsta resursaTekst
Prava pristupaOgraničen pristup
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Datum i vrijeme pohrane2022-02-23 12:11:03