prikaz prve stranice dokumenta Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.
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Scientific paper - Original scientific paper
Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.
Journal of Physiology and Biochemistry, 72 (2016), 3; 405-419. https://doi.org/10.1007/s13105-016-0491-7
Detel, Dijana; Buljević, Sunčica; Batičić Pučar, Lara; Kučić, Natalia; Pernjak Pugel, Ester; Varljen, Jadranka

Cite this document

Detel, D., Buljević, S., Batičić Pučar, L., Kučić, N., Pernjak Pugel, E. & Varljen, J. (2016). Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.. Journal of Physiology and Biochemistry, 72. (3), 405-419. doi: 10.1007/s13105-016-0491-7

Detel, Dijana, et al. "Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.." Journal of Physiology and Biochemistry, vol. 72, no. 3, 2016, pp. 405-419. https://doi.org/10.1007/s13105-016-0491-7

Detel, Dijana, Sunčica Buljević, Lara Batičić Pučar, Natalia Kučić, Ester Pernjak Pugel and Jadranka Varljen. "Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.." Journal of Physiology and Biochemistry 72, no. 3 (2016): 405-419. https://doi.org/10.1007/s13105-016-0491-7

Detel, D., et al. (2016) 'Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.', Journal of Physiology and Biochemistry, 72(3), pp. 405-419. doi: 10.1007/s13105-016-0491-7

Detel D, Buljević S, Batičić Pučar L, Kučić N, Pernjak Pugel E, Varljen J. Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.. Journal of Physiology and Biochemistry [Internet]. 2016 [cited 2024 November 12];72(3):405-419. doi: 10.1007/s13105-016-0491-7

D. Detel, S. Buljević, L. Batičić Pučar, N. Kučić, E. Pernjak Pugel and J. Varljen, "Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.", Journal of Physiology and Biochemistry, vol. 72, no. 3, pp. 405-419, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:230306. [Accessed: 12 November 2024]

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Metadata
Title (english)Influence of CD26/dipeptidyl peptidase IV deficiency on immunophenotypic changes during colitis development and resolution.
AuthorDijana Detel
AuthorSunčica Buljević
AuthorLara Batičić Pučar
AuthorNatalia Kučić
MBZ: 239812
AuthorEster Pernjak Pugel
AuthorJadranka Varljen
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Chemistry and Biochemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Medical Biochemistry
Abstract (english)
A lot of evidence for the importance of CD26/dipeptidyl peptidase IV (CD26/DPP IV) in immunoactivation has been reported ; however, its involvement in colitis remains unclear. The aim of this study was to investigate the influence of CD26/DPP IV deficiency on immunophenotypic changes associated with dextran sulfate sodium (DSS)-induced colitis in wild- type (WT) and CD26-deficient mice. Development of clinical symptoms of colitis and animal health status parameters were assessed ; the expression of the nuclear factor (NF)-κB p65 subunit was measured by quantitative real-time PCR, while cell characterization was determined by flow cytometry and immunohistochemical staining. DSS treatment induced loss of body weight and colon length shortening in both mouse strains. An increase of myeloperoxidase activity in CD26-deficient mice was more intensive than in WT mice, in spite of similar histopathological changes. Furthermore, a significant increase in the expression of NF-κB p65 subunit in the colon of CD26-deficient mice was determined. The percentage of splenic CD4+ and CD8+ cells in the acute phase of colitis was significantly decreased in WT mice, while in the same period, an increase in the percentage of splenic CD8+ cells was present in CD26-deficient mice. Development of colitis was accompanied by a significant increase in the percentage of intrahepatic NKT cells in both mouse strains, but their percentage in spleen was increased only in CD26-deficient mice. CD26 deficiency was associated with a heightened response to DSS accompanied by increased expression of NF-κB p65 subunit and distinct changes in leukocyte trafficking. These results provide new insights into the role of CD26/DPP IV during the development of colitis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Physiology and Biochemistry
Numberingvol. 72, no. 3, pp. 405-419
p-ISSN1138-7548
DOIhttps://doi.org/10.1007/s13105-016-0491-7
URN:NBNurn:nbn:hr:184:230306
Publication2016
ProjectNumber: 062-0061245-0213
Title (croatian): Uloga dipeptidil-peptidaze IV (CD26/DPP IV) u kroničnim bolestima
Title (english): The role of dipeptidyl peptidase IV (CD26/DPP IV) in chronic diseases
Leader: Jadranka Varljen
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://bib.irb.hr/820380
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2022-02-23 12:11:03